M2 protein of 95 aas and 1 TMS, AM2. This protein shows 28% identity, 50% similarity and 10% gaps with BM2 (TC# 1.B.58.1.1) with residues 8 - 65 aligning with residues 26 - 81. AM2 forms a range of oligomeric complexes that are strongly influenced by the local chemical environment. Native mass spectrometry of AM2 in nanodiscs with different lipids showed that lipids also affected the oligomeric states of AM2. Finally, nanodiscs uniquely enabled the measurement of amantadine binding stoichiometries to AM2 in the intact lipid bilayer (Townsend et al. 2021).
|Protein Name:||Matrix protein 2|
|Species:||Influenza A virus (A/herring gull/Newfoundland/GR657/2011(H13N6))  |
|Number of TMSs:||1|
|Location1 / Topology2 / Orientation3:
1: MSLLTEVETP IRNEWECKCS DSSDPLVIAA SIIGILHLIL WILDRLFFKC IYRRIKYELK
61: RGPSKEGVPE SMREEYRQEQ QNAV