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| Accession Number: | P77338 |
| Protein Name: | KefA aka AEFA aka B0465 |
| Length: | 1120 |
| Molecular Weight: | 127215.00 |
| Species: | Escherichia coli [83333] |
| Number of TMSs: | 11 |
| Location1 / Topology2 / Orientation3: | Cell inner membrane1 / Multi-pass membrane protein2 |
| Substrate | ion, chloride, potassium(1+), water |
Cross database links:
| DIP: | DIP-10070N |
|---|---|
| RefSeq: | AP_001114.1 NP_414998.1 |
| Entrez Gene ID: | 945132 |
| Pfam: | PF00924 |
| BioCyc: | EcoCyc:G6255-MONOMER ECOL168927:B0465-MONOMER |
| KEGG: | ecj:JW0454 eco:b0465 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0008381
F:mechanically-gated ion channel activity
GO:0009992
P:cellular water homeostasis
GO:0006813
P:potassium ion transport
GO:0055085
P:transmembrane transport
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References (4)[1] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [3] “Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity.” Levina N.et.al. 10202137 [4] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MTMFQYYKRS RHFVFSAFIA FVFVLLCQNT AFARASSNGD LPTKADLQAQ LDSLNKQKDL 61: SAQDKLVQQD LTDTLATLDK IDRIKEETVQ LRQKVAEAPE KMRQATAALT ALSDVDNDEE 121: TRKILSTLSL RQLETRVAQA LDDLQNAQND LASYNSQLVS LQTQPERVQN AMYNASQQLQ 181: QIRSRLDGTD VGETALRPSQ KVLMQAQQAL LNAEIDQQRK SLEGNTVLQD TLQKQRDYVT 241: ANSARLEHQL QLLQEAVNSK RLTLTEKTAQ EAVSPDEAAR IQANPLVKQE LEINQQLSQR 301: LITATENGNQ LMQQNIKVKN WLERALQSER NIKEQIAVLK GSLLLSRILY QQQQTLPSAD 361: ELENMTNRIA DLRLEQFEVN QQRDALFQSD AFVNKLEEGH TNEVNSEVHD ALLQVVDMRR 421: ELLDQLNKQL GNQLMMAINL QINQQQLMSV SKNLKSILTQ QIFWVNSNRP MDWDWIKAFP 481: QSLKDEFKSM KITVNWQKAW PAVFIAFLAG LPLLLIAGLI HWRLGWLKAY QQKLASAVGS 541: LRNDSQLNTP KAILIDLIRA LPVCLIILAV GLILLTMQLN ISELLWSFSK KLAIFWLVFG 601: LCWKVLEKNG VAVRHFGMPE QQTSHWRRQI VRISLALLPI HFWSVVAELS PLHLMDDVLG 661: QAMIFFNLLL IAFLVWPMCR ESWRDKESHT MRLVTITVLS IIPIALMVLT ATGYFYTTLR 721: LAGRWIETVY LVIIWNLLYQ TVLRGLSVAA RRIAWRRALA RRQNLVKEGA EGAEPPEEPT 781: IALEQVNQQT LRITMLLMFA LFGVMFWAIW SDLITVFSYL DSITLWHYNG TEAGAAVVKN 841: VTMGSLLFAI IASMVAWALI RNLPGLLEVL VLSRLNMRQG ASYAITTILN YIIIAVGAMT 901: VFGSLGVSWD KLQWLAAALS VGLGFGLQEI FGNFVSGLII LFERPVRIGD TVTIGSFSGT 961: VSKIRIRATT ITDFDRKEVI IPNKAFVTER LINWSLTDTT TRLVIRLGVA YGSDLEKVRK 1021: VLLKAATEHP RVMHEPMPEV FFTAFGASTL DHELRLYVRE LRDRSRTVDE LNRTIDQLCR 1081: ENDINIAFNQ LEVHLHNEKG DEVTEVKRDY KGDDPTPAVG