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1.A.23.3.3
Mechanosensitive channel, small conductance, YggB, GluE or MscCG (533 aas; 6-7 TMSs).  Mediates glutamate efflux (Becker et al. 2013).  The pore domain is in the N-terminus.  The C-terminus includes three subdomains, the periplasmic loop, the fourth transmembrane segment, and the cytoplasmic loop, all of which are important for MscCG function, in particular for glutamate excretion (Becker and Krämer 2015). Deletion of the encoding gene results in a 10% increase in lysine production and a decrease in cell mass yield (Xiao et al. 2020).  

Accession Number:P42531
Protein Name:Uncharacterized protein Cgl1270/cg1434
Length:491
Molecular Weight:52551.00
Species:Corynebacterium glutamicum [1718]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass membrane protein2
Substrate ion

Cross database links:

Entrez Gene ID: 1019251    3344539   
Pfam: PF00924   
KEGG: cgb:cg1434    cgl:NCgl1221    cgb:cg1434    cgl:NCgl1221   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0055085 P:transmembrane transport

References (4)

[1] “The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.”  Kalinowski J.et.al.   12948626
[2] “Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon.”  Keilhauer C.et.al.   8366043
[3] “The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.”  Kalinowski J.et.al.   12948626
[4] “Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon.”  Keilhauer C.et.al.   8366043

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MRIIKRRVES AADADTTKNQ LAFAGVGVYI AQIVAFFMLA VSAMQAFGFS LAGAAIPATI 
61:	ASAAIGLGAQ SIVADFLAGF FILTEKQFGV GDWVRFEGNG IVVEGTVIEI TMRATKIRTI 
121:	AQETVIIPNS TAKVCINNSN NWSRAVVVIP IPMLGSENIT DVIARSEAAT RRALGQEKIA 
181:	PEILGELDVH PATEVTPPTV VGMPWMVTMR FLVQVTAGNQ WLVERAIRTE IISEFWEEYG 
241:	SATTTSGTLI DSLHVEHEEP KTSLIDASPQ ALKEPKPEAA ATVASLAASS NDDADNADAS 
301:	VINAGNPEKE LDSDVLEQEL SSEEPEETAK PDHSLRGFFR TDYYPNRWQK ILSFGGRVRM 
361:	STSLLLGALL LLSLFKVMTV EPSENWQNSS GWLSPSTATS TAVTTSETSA PVSTPSMTVP 
421:	TTVEETPTME SNVETQQETS TPATATPQRA DTIEPTEEAT SQEETTASQT QSPAVEAPTA 
481:	VQETVAPTST P