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1.A.23.4.11
Mitochondrial mechanosensitive ion channel protein 1, MscS-like channel, MSL1, of 497 aas and 5 TMSs. As the sole member of the Arabidopsis MSL family, localized in the mitochondrial inner membrane, MSL1 is essential for maintaining the normal membrane potential of mitochondria. Li et al. 2020 reported a cryoelectron microscopy (cryo-EM) structure of AtMSL1 at 3.3 Å. The overall architecture of AtMSL1 is similar to MscS, but the transmembrane domain of AtMSL1 is larger. Structural differences are observed in both the transmembrane and the matrix domain, and the carboxyl-terminus of AtMSL1 is more flexible while the beta-barrel structure observed in MscS is absent. The side portals in AtMSL1 are significantly smaller, and enlarging the size of the portal by mutagenesis can increase the channel conductance (Li et al. 2020).

Accession Number:Q8VZL4
Protein Name:Mechanosensitive ion channel protein 1, mitochondrial
Length:497
Molecular Weight:53884.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Structure:
6LYP   6VXM   6VXN   6VXP     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGVRLSLLK SIQRSIKPHA TAKSCSGLLN SHARAFTCGN LLDGPKASPS MISFSSNIRL 
61:	HNDAKPFNYL GHSSYARAFS SKSDDFGSIV ASGVTGSGDG NGNGNDWVEK AKDVLQTSVD 
121:	AVTETAKKTK DVSDEMIPHV QQFLDSNPYL KDVIVPVSLT MTGTLFAWVV MPRILRRFHT 
181:	YAMQSSAKLL PVGFSNEDVP YEKSFWGALE DPARYLVTFI AFAQIAAMVA PTTIAAQYFS 
241:	PTVKGAVILS LVWFLYRWKT NVITRMLSAK SFGGLDREKV LTLDKVSSVG LFAIGLMASA 
301:	EACGVAVQSI LTVGGVGGVA TAFAARDILG NVLSGLSMQF SRPFSMGDTI KAGSVEGQVI 
361:	EMGLTTTSLL NAEKFPVLVP NSLFSSQVIV NKSRAQWRAI ASKIPLQIDD LDMIPQISNE 
421:	IKEMLRSNTK VFLGKEAPHC YLSRVEKSFA ELTIGCNLIR MGKEELYNTQ QEVLLEAVKI 
481:	IKKHGVSLGT TWDNSTL