1.A.23.4.17
MscB (AN6053) of 943 aas, a mechanosensitive channel in the PM membranes of filamentous fungi. It may have 6 or 7 TMSs in a 4 + 2 or 3 TMS arrangement, but
there are also two moderately hydrophobic peaks near the C-terminus of
the protein that might be TMSs. Orthologues of MscA and MscB are present
in most fungi, including plant and animal pathogens. MscA/MscB and
other fungal MscS-like proteins share the three TMSs and the extended
C-terminal cytosolic domain that form the structural fingerprint of
MscS-like channels (Dionysopoulou et al. 2022). Their overexpression leads to increased CaCl2 toxicity or/and reduction of asexual spore formation.
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| Accession Number: | Q5B077 |
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| Protein Name: | Mechanosensitive ion channel protein |
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| Length: | 943 |
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| Molecular Weight: | 103476.00 |
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| Species: | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [227321] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 |
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| Substrate |
ion |
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1: MPNPNDVTID IPLTSVSSRG QTGARNNSTN IPNSPSGGYS AGAEHNGGAE KGGLTSSPPS
61: SSLGFGHRRR RTINDKTGLP AEEPEDGTVT RMGRFYQAVL NFSTVTRYLI YIAPLAALLA
121: IPIIVGATAA EDAKIGGVSL PWFFCWVEVV WVSLWVCKLV AKVIPFVFQF VCGIVSAGTR
181: KYALILRNLE IPITMVLWMI VSLVTFLPIM VYNPRNKREG DTETKSWEKS VKNVLFAFLV
241: CALIFLGEKT LVQLISISYH RKQFDARIKE SKRNINLIGI LYDASRSMFP MYCKEFREDD
301: AIISDSILLG GPETGRPGHS RSNSAAPLRF IRGVQQNVGR IGGKITGALG DVAHEITGKQ
361: VFNSSAARSI VSEALERRRS SEALARRIWM SFVIEGREAL YLDDIMEVLG AGKEAEAEEC
421: FTMLDRDGNG DISLDEIILA ISEIGRTRKT LNHSVHDVDQ AIHVLDNLLA TIAFIIAVLV
481: FVSFVTSGFG TVIAAGATSL LSLSFVFATT AQEVLGSCIF LFVKHPFDIG DRVEIDSKPY
541: IVQRISLLYS VFRNVNDNRV TQIPNVVLNT VWIDNYSRSS AMQEKLTIEV NIDTTTEEIQ
601: ALKDEIETFV RSPDNKRDFH PDVDIEVSGV GALDKLELTV GLFHKSNWAI ESVRAARRSK
661: FMVALVAAVK KVPIRTPGAA AEDAAAADGD RPDDKPDDAE QPPARQSSIS EGIRHPTVPD
721: DSFPSDSKST GVDLGRPGSV QRRGASATAA TGNNSAGSAY SETTLNNTVS EPYQRSFTPN
781: TGDRDTDHYH GSMSSPVTER HLGVSHDSIA RKASTASTGR RRAGIMTTAN QSLASPTTMQ
841: SESALPPHLQ PPPPLQPSSS QYSQQYPQQQ SQSPYSYTYS ERYDQPESSL QPLEHTTSYN
901: QSLPQVYEYA PAADRNSLEG HSPHVDPRHM TEEQRRNYES RRL