1.A.23.4.18
Msy1 mechanosensitive calcium channel in response to hypo-osmotic shock. The protein is of 1011 aas with 6 or 7 TMSs in a 4 + 2 or 3 TMS arrangement. It regulates intracellular calcium levels and cell volume for survival in
response to hypo-osmotic shock. The conductance is about 0.25
nanosiemens (Nakayama et al. 2012). It is involved in maintaining vacuole integrity and protecting the nuclear envelope upon hypo-osmotic shock (Nakayama et al. 2014).
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| Accession Number: | O74839 |
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| Protein Name: | Mechanosensitive ion channel protein Msy1 |
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| Length: | 1011 |
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| Molecular Weight: | 114270.00 |
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| Species: | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ion |
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1: MSSPTSPTSS PGRHHWSNSK DGMPPEYTNQ DPNSDQADNE NSDAKAHQPQ HSPQHSTENQ
61: GHTGTSDTSS LEMELSKLHP ESKQRQLPHS PEHERSRSPI ASVVSYRSHM TLEDENQIFN
121: AEMAVRGSQS LQRRPTGRSV RGSMRRLSSH RSKSMRTSKS KKSGDYERTA ENEEAAQEAE
181: NHLDNFGVVT FGTEAPIKAP DHPVTIFGRI FKFIQQRSFY LRSLIYIIPL GVLLLIPVFI
241: GRFYHPQPPY RDELGHEYER HLHVGGVDLM WMAIWWEIIW LSIWAARYAA KVIPYFFAFF
301: VSFISNNVTK WRCMAVALEF PITLFLWMLA VYVSFLPIMT RRHIGDYGVP DHVRVKLPWQ
361: QSANNVLITL FITSIMNLVE KVLMQLIAMS LHRREYESRI LYNKFAINEL ARLYGYARQR
421: SFDFKDAIHR AQADVFKFAD HQHGKKRAAA ARVAQNALNK TTYKAISAFN FATDMVNKVA
481: GEITNREVEK SSSPKSVVLH LLKTTRGCQS LARCLFEALV NPENPDLVLD DFIPVYTDET
541: GEVDNATLEA CYSIFDRDLN GDITCEEIEL ACVEIGKERK SISASLRDLN DSISKLDGIC
601: MFIVAVITLF IFLYLIARNF SGVLTSAGTT LLGLSWLFSG SAQELLSSII FVFVKHPYDV
661: GDRVDVMING TVTSAMVKEI SIMSTEFRLL TGKVIQAPNS LLNTLWILNM RRSDGIADPV
721: TVNLKFGTTL QQIEQLRIKI IDFLKEEKRD YKPDLLTEVT DLPDLYSMSL CVVFFHKYNF
781: QDEVLRMRRR NMFMCALMTY MQELDIVSPI FNSPGKSKDS PMYVNFNNGS MEGVKLSGGN
841: DGGGTENHRD STVGGGILKN PKAYPYREPT PPGSSDSDTA SVSKKRVDFS LGTRHLMPAF
901: DDVADIGSKR LGRDSLPDAV IENAGTEAMR REAEERRRAE EEEYERSQQE SSSNEENENA
961: SRTSGARFSF SSKASRLSAR PSARTVPPLQ HISIQDLREP NENNTSKSAR L