1.A.23.4.19
Msy2 of 840 aas and 7 or 8 TMSs in a 4 + 1 + 2 or 3 TMS arrangement. It regulates intracellular calcium levels and cell volume for survival in response to hypo-osmotic shock (Nakayama et al. 2012)., and is involved in maintaining vacuole integrity while protecting the nuclear envelope from hypo-osmotic shock (Nakayama et al. 2014).
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| Accession Number: | O14050 |
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| Protein Name: | Mechanosensitive ion channel protein Msy2 |
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| Length: | 840 |
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| Molecular Weight: | 94644.00 |
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| Species: | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ion |
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1: MNEHRREPHR RSGYQDDSAF TNTEKLVDEL DHNVEPEQLL EKNRTDFKLM YVIVKFYRWF
61: NNLSFITRWI TIWFPLAGAL VIPLAVGVSP YPNAKLGGVR IFWIFVWLEV AWGGFWVSRV
121: IARLLPYILY PLMGILPFTM YKYTVILTAL EMPLAIFFCS IVCVCTFSPI MIGKGNFTST
181: TVTTTTSATA TPTASASSNA VESVFVTKTA ASVPSWIKVI TKILGAAVVT SIVLLLEKIF
241: LHFIGFHYHE VQYQYRITDN KRNTAVLAKL LTAALDAPYH DSPRVRRQDY LLGLIDTRSM
301: SESKGSGNGK LRKVKKISKN AKRIFSKTRN AISTAFTDML GKHAKDLTPE QEFILETIRS
361: KKKCLALARK IWYSLVPEGE DCFQKEDLIG LIPDDEINDI FHILDNDYSR TVTLDEMEQF
421: TREISIEFRS ISSSLRDVDL ALGKLDRVGL GVVGIIAVLT FISFLDTSFA TILAAFGTTL
481: LSLSFVFSTS AQELMSSIIF LFSKHPFDIS DVVIVNNIKY EVVSLSLLFT VFRTMGGSTV
541: QAPNSLLNTL FIENLRRSQP QSETITIVSP FATDFKQLER LRDLLLTFVK ENERDFRPII
601: DLNVSDFSTL DSLKFTVTYY YKSNWQNVSL QCVRRNKFMC ALKNAIATTN LPAVADPVRG
661: SPDYPFVIEQ YNLERPEYSK TASRPQFSDI SSTASSNSLS NKPGFAHSES RNYHTHDEDN
721: SSDDNHKRED RGHLPAQYLR QSVATWQIPN LISAIEAYDS QNESSQENAT YTVVESNGNA
781: NGDNTATNSQ GATDNGQTTT NTTQNNVDNT QATTDNTQAN TDNMQVAIDY SQNMDGQIQY