1.A.23.4.7
Mechanosensitive ion channel protein 8 (Mechanosensitive channel of small conductance-like 8) (MscS-Like protein 8) is
a pollen-specific, membrane tension-gated ion channel required for
pollen to survive the hypoosmotic shock of rehydration and for full male
fertility. It negatively regulates pollen germination but is required for cellular integrity during germination and tube growth. MSL8 thus senses and responds to changes in membrane tension associated with pollen hydration and germination (Hamilton et al. 2015).
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| Accession Number: | F4IME2 |
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| Protein Name: | Mechanosensitive ion channel protein 8 |
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| Length: | 908 |
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| Molecular Weight: | 104309.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ion |
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| Entrez Gene ID: |
816204
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| Pfam: |
PF00924
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| KEGG: |
ath:AT2G17010
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[1] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.” Lin X. et.al. 10617197
[2] “Two families of mechanosensitive channel proteins.” Pivetti C.D. et.al. 12626684
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1: MDFRNSFKSH SSYKQIRSPG DQSEPSPEHL PILHDHHPDH SGMVVDDQKP DSTRSSLDDG
61: RNAPVERDAS YKFWQDNTTG TSTDHTAVRT SDKDPIAISR KGDRLSGSFD FVHGKLPVDE
121: SPTKMVAGEP VNRQWRGRNN EEITLDVDQE NDDVSHQTMP TPTSTARTSF DASREMRVSF
181: NVRRAGGAFV AGSVPSSSSH SSSSSSATMR TNQDQPQLQE EEVVRCTSNM SFQRKSELIS
241: RVKTRSRLQD PPREEETPYS GWRSGQLKSG LLADIDEEDD PLAEEDVPDE YKRGKLDAIT
301: LLQWLSLVAI IAALACSLSI QSWKKVRVWN LHLWKWEVFL LVLICGRLVS GWGIRIVVFF
361: IERNFLLRKR VLYFVYGVRR AVQNCLWLGL VLLAWHFLFD KKVQRETRSR FLPYVTKILV
421: CFLLSTILWL IKTLVVKVLA SSFHVSTYFD RIQEALFNQY VIETLSGPPM IEMSRIEEEE
481: ERAQDEIFKM QNAGANLPPD LCAAAFPPGK SGRVMNPKLS PIIPKSTTDN GISMEHLHRM
541: NHKNISAWNM KRLMKIVRNV SLTTLDEQML ESTYEDESTR QIRSEKEAKA AARKIFKNVE
601: QRGAKYIYLE DLMRFLREDE AMKTMGLFEG APENKRISKS ALKNWLVNAF RERRALALTL
661: NDTKTAVNKL HHMINIVTAI VIVVIWLVLL EIASSKVLLF VSSQVVLLAF IFGNTVKTVF
721: ESIIFLFIVH PYDVGDRCEI DSVQLVVEEM NILTTVFLRY DNLKIMYPNS LLWQKSINNY
781: YRSPDMGDAI EFCVHITTPL EKISVIKQRI SNYIDNKPEY WYPQAKIIVK DLEDLHIVRL
841: AIWPCHRINH QDMAERWTRR AVLVEEVIKI LLELDIQHRF YPLDINVRTM PTVVSSRVPP
901: GWSQNQPA