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1.A.23.5.1 The cyclic nucleotide-binding MscS homologue, MT2508 (the C-terminal domain is the CAP_ED domain CD00038). It lacks mechanosensitivity but is ligand-gated by cyclic nucleotides (Caldwell et al., 2010).
Accession Number:	P71915
Protein Name:	MscS homologue, MT2508
Length:	481
Molecular Weight:	52273.00
Species:	Mycobacterium tuberculosis [1773]
Number of TMSs:	5
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	ion

RefSeq:	NP_216950.1 NP_336991.1
Entrez Gene ID:	885885 925815
Pfam:	PF00027 PF00924
KEGG:	mtc:MT2508 mtu:Rv2434c
Gene Ontology GO:0016021 C:integral to membrane GO:0055085 P:transmembrane transport
References (2) [1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.” Cole S.T.et.al. 9634230 [2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.” Fleischmann R.D.et.al. 12218036

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MNLLDSTWFY WAVGIAIGLP AGLIVLTELH NILVRRNSHL ARQASLLRNY LLPLGAVLLL 
61:	LVKASEVPAE DPTVRVLTTA FGFLVLVLLL SLLNATLFQG APQQSWRKRL PAIFVDVARF 
121:	ALIGIGLAVI LSYIWGVRVG GLFAALGVTS VVIGLMLQNS VGQIVSGLFM LFEQPFRIDD 
181:	WLETPTARGR VVEVNWRAVH IDTGSGLQIM PNSMLATTAF TNLSRPAGAH ECSITTTFST 
241:	SDPPDKVCAM LNRAASALPH VKPGVVPATI ARGAAEYRTT VRLTSPADEG PTQATFLRWV 
301:	WYAARREGLH LDEADDEFST AERVESALRT VVGPELRLSS SDQQSLARYA RLVRYGTDEI 
361:	VQHAGVVPMG ITFVIAGSVR LTVTTDDGSV VAIATLKKGT FLGLTALTRQ PDPAGAVALE 
421:	EVTALQIGRE HLEQVVMNKP MLLQELGRVI DERQRKAQQA IRRDLHQSPA AAGEHRGPAR 
481:	R

1.A.23.5.1
The cyclic nucleotide-binding MscS homologue, MT2508 (the C-terminal domain is the CAP_ED domain CD00038). It lacks mechanosensitivity but is ligand-gated by cyclic nucleotides (Caldwell et al., 2010).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

1.A.23.5.1The cyclic nucleotide-binding MscS homologue, MT2508 (the C-terminal domain is the CAP_ED domain CD00038). It lacks mechanosensitivity but is ligand-gated by cyclic nucleotides (Caldwell et al., 2010).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

1.A.23.5.1
The cyclic nucleotide-binding MscS homologue, MT2508 (the C-terminal domain is the CAP_ED domain CD00038). It lacks mechanosensitivity but is ligand-gated by cyclic nucleotides (Caldwell et al., 2010).