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|---|---|
| Accession Number: | Q8BQU6 |
| Protein Name: | Gap junction alpha-12 protein aka Connexin-47 |
| Length: | 440 |
| Molecular Weight: | 47008.00 |
| Species: | Mus musculus (Mouse) [10090] |
| Number of TMSs: | 4 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | |
Cross database links:
| RefSeq: | NP_536702.3 NP_780661.2 |
|---|---|
| Entrez Gene ID: | 118454 |
| Pfam: | PF00029 PF10582 |
| KEGG: | mmu:118454 |
Gene Ontology
GO:0005922
C:connexon complex
GO:0016021
C:integral to membrane
GO:0005243
F:gap junction channel activity
GO:0007267
P:cell-cell signaling
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References (7)[1] “Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons.” Teubner B.et.al. 11160382 [2] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [3] “Variable promoter usage and alternative splicing in five mouse connexin genes.” Anderson C.L.et.al. 15676282 [4] “Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS.” Odermatt B.et.al. 12805295 [5] “Connexins are critical for normal myelination in the CNS.” Menichella D.M.et.al. 12843301 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MTNMSWSFLT RLLEEIHNHS TFVGKVWLTV LVVFRIVLTA VGGESIYSDE QSKFTCNTRQ 61: PGCDNVCYDA FAPLSHVRFW VFQIVVISTP SVMYLGYAVH RLARASEQER RRALRRRPGT 121: RRLPRAQLPP PPPGWPDTTD LGEAEPILAL EEDEDEEPGA PEGPGEDTEE ERAEDVAAKG 181: GGGDGKTVVT PGPAGQHDGR RRIQREGLMR VYVAQLVVRA AFEVAFLVGQ YLLYGFEVPP 241: FFACSRQPCP HVVDCFVSRP TEKTVFLLVM YVVSCLCLLL NLCEMAHLGL GSAQDAVRGR 301: RGASAAGPGP TPRPPPCAFP AAAAGLACPP DYSLVVRAAE RARAHDQNLA NLALQALRDG 361: AAVAAVSADR DSPPCAGLNA TSRGAPRVGG LASGTGSATS GGTVGEQSRP GAQEQLATKP 421: RAGSEKGSTG SRDGKATVWI