1.A.3.1.8
Ryanodine receptor, DcRyR shows high sequence identity to RyRs from other insects (76%-95%) and shares many features of insect and vertebrate RyRs, including a MIR domain, two RIH domains, three SPRY domains, four copies of RyR repeat domain, an RIH-associated domain at the N-terminus, two consensus calcium-binding EF-hands and six TMSs at the C-terminus (Yuan et al. 2017). The expression of DcRyR mRNA was the highest in the nymphs and lowest in eggs; it has three alternative splice sites, and the splice variants showed body part-specific expression, being under developmentally regulation (Yuan et al. 2017).
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| Accession Number: | AKM95170 |
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| Protein Name: | AKM95170.1 ryanodine receptor [Dialeurodes citri] |
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| Length: | 5127 |
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| Molecular Weight: | |
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| Species: | Dialeurodes citri [298404] |
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| Number of TMSs: | 6 |
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| Substrate |
inorganic cation, calcium ion |
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1: MTEADGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNIPPDLS
61: QCVFVIEQAL SVRALQELVT AAGSEQEQGS IGKGTGSGHR TLLYGNAILL RHHNSEMYLA
121: CLSTSSSNDK LSFDVGLQEH SQGEACWWTV HPASKQRSKG EKVRVGDDLI LVSVATERYL
181: HTAKENDLSV VNASFHVTHW SVQPYGTGIS RMKYVGYVFG GDVLRFFHGG DECLTIPSNW
241: TEVPGQNIVI YEGGSVMSQA RSLWRLELAR TKWAGAFINW YHPMRIRHLT TGRYLSVNEN
301: NELHLVGRDE ATTATSTFCL RQEKDDQKVV LEDKDLEVIG APIIKYGDST VLVQHSETGL
361: WLTYKAYETK KKGVGKVEEK QAVLHEEGKM DDGLDFSRSQ EEESRTARVI RKCSHLFTQF
421: IKGLETLQTN RRQSVFTSSV NLNEMVMCLE DLINYFAQPE EDMEHEEKQN RLRALRNRQD
481: LFQEEGILNL ILEAIDKISV ITSQGLMVNL GGDESGQCWD VISGYLYQLL AAIIRGNHTN
541: CAQFANSNRL NWLFSRLGSQ ASSEGTGMLD VLHCVLIDSP EALNMMRDEH IKVIISLLEK
601: HGRDPKVLDV LCSLCVGNGV AVRSSQNNIC DFLLPGKNLL LQTQLVDHVA SVRPNIFVGR
661: VEGSAVYQKW YFEVTLDHVE KTTHMTPHLR IGWANTAGYV PYPGGGEKWG GNGVGDDLYS
721: FGFDGAYLWT GGKTTNVNPE ATEPFIKKGD VIGCALDLTI PVVTFSFNGH PVRGHFRDFN
781: VDGMFFPVIS ASSKLSCRFL LGGDHGRLKY VPPEEFSPLV ESLLPQQILS IDPCFYFGNL
841: NKCTLAGPWP VEDDTAFVPA PVDTSMINLP SYIENIRDRL AENIHEMWAL NKIEAGWQYG
901: ELRDDIRKIH PCLVQFDRLP PAEKRYDSQL AVQTLKTILA LGYHITMDKP SSRIKTIRLP
961: NEPFMQSNGY KPAPLDLAAI TLNVKMEELV DQLAENTHNL WAKERIQQGW TYGLNEDPDM
1021: LRSPHLVPYA EVDDAIKKAN RDTASETVRT LLVYGYMLDP PTGEANEAAL LAEANRIRQM
1081: TFRTYRVEKN YAVTSGKWYF EFEVLTTGPM RVGWARVDCG PGYQLGSDEN SWAFDGFNEE
1141: KVRCNAAEQF GRQWQVGDIV GACLDLMDRT ISFSLNGELL MDALGGETTF SDVQGEAFVP
1201: AFTLGVGQRA KLTFGQDVNL LKFFTVCGLQ EGYEPFCVNM NRAVTYWYTK DQPIFENTDD
1261: YPSPFDVTRI PAGSDTPPCL KISHNTFETM EKANWEFLRL SLPIICLPEF IDEAEKMRRW
1321: QEIRIRQHRL LAEADKTTPA HIEQIMKSGF SMSDIKGLHR NYSGDAVEAD EMMMNGGGAG
1381: PIQSKSKKGP SRPPRKGSLS RNEDLQMDSV MPSGKIHRSS SELDVNRYST MNGNMGDIKD
1441: DKKKRGRSPF RFFSRKRDQS GERGKKAKTP EPSSLAVDRM EGMGQSRTGH PFRTSQANIK
1501: LVPPAIPDRT PTGPKQMSGS PLTSSGVEAI GNEIYDVECL KMMNEYFYGV RIFPGQDPTH
1561: VYIGWVTTQY HLHSGTFNQS HVRQSNITVI DDYGRVVDSI NRQSCYMLRA DELYNEVTND
1621: ASGKGASQGM FIGCFIDTAT GIMSFTCEGK ETSHKYKMEP EAKLFPAIFV EATSKEVLQI
1681: ELGRTSTTLP LSSAILQNSE RHVTPQFPPR LKVQCLRPHQ WARVPNVSLQ VHALKLSDVR
1741: GWSMLCEDPV SMLALHIPEE DRCIDILELI EMEKLLSFHA HTLTLYAALC YQANYRAAHT
1801: LCQHVDQKQL LYAIRSEYMS GPLRQGFYDL LIALHLDPHA TTMEACKNEY IIPLGQELKD
1861: LYEDAQMGHS LRCLKTESVQ PVMKMTNIAE TVDNIRNLYS PFFPLDVVRD YVMMALDEAV
1921: QINHVHNRDP VGSNENLFLP LLKLVDRLLL VGILRDEDVE KLLIMFDPET WDSFFERDGK
1981: DEHRKGLFHM KMAEGAKLQM CYLLNHLGDL QLRHRVESII SFSHDFVGEI QSDQLRRYID
2041: IKQSDLPSAV AAKKTKEFRC PPREQMNAVL GFKNLEENDY ENSPCGDELR QRMNEFHTSV
2101: MRHVSLLALQ EPTEEEEKKD DIAKPNMFKR LTNFINAVKE LEEEPKPPEE PEKKSPEEIF
2161: RKVLISTIVK WAEESQIEMP KLVREMFSLL VRQYDSVGEL IRALEKTYII NNKTKGDAAG
2221: MWVGLSQIRS LLPVQMSQEE EGLMRERLWK LVNNHTFFQH PDLIRILRVH ENVMAIMINT
2281: LGRRAQAQSD APQAGTGAME GEPVAKEKDT SHEMVVACCR FLCYFCRTSR QNQKAMFDHL
2341: SFLLENSNIL LSRPSLRGST PLDVAYSSLM ENTELALALR EHYLEKIAIY LSRCGLQSNS
2401: ELVEKGYPDL GWDPVEGERY LDFLRFCVWV NGESVEENAN LVIRLLIRRP ECLGPALRGE
2461: GEGLLRAIMD ANKMSEQIAD RKKLMDEAEG STAVMQFEHP LPESDEDEDY IDTGAAILNF
2521: YCTLVDLLGR CAPDASVIAQ GKNESLRARA ILRSLVPLED LLGVLSLRFT LQNPAAGEER
2581: PKSDMPSGLI PGHKQSVVLF LERVYGIEQQ DLFFKILEEA FLPDLRAATM LDRNDGLESE
2641: MALAMNRYIG NSILPLLISH SRFYNESDNY ANLLDATLHT VYRLSKNRML TKGQREAVSD
2701: FLVALTSQMQ PSMLLKLLRK LTVDVSTLSE YTTVALRLLT LHYDRCAKYY GSTGGQGLYG
2761: ASSEEEKRLT MMLFSNIFDS LSKMDYDPEL FGKAPPCLIA IGCALPPDYS LSKNYDDEWY
2821: GSKTQVQTGP ADGPYNPQPI NTSSVQLNND LNTIVQKFSE HYHDAWASRK LENGWVYGEQ
2881: YSESQKAHPR LKPYAMLNDY EEKERYKEPV RESLKALLAI GWSVEHTEVD VPITNRNSVR
2941: RQSKATLDTA TPFNYRPNPI DMTNLTLSRE VQNMAERLAE NAHDIWAKKK KEESVTCGGG
3001: IHPQLVPYDL LTDKEKRKDR ERSQEFLKYL QYQGYKLHRP SRGTATSEAE QLAAVQTGEL
3061: RFAYSLLEKL IQYMDKASIN MKLLKPSATF SRRSSFKTCT RDIKFFSKVV LPLVEKYFSS
3121: HRNYFIVVAT ASNNVGAASL KEKEMVASLF CKLASLLRSR LAAFGADVRI TVRCLQTLVK
3181: GIDARSLVKN CPEFIRTSML TFFNNTADDL GHTIINLQEG KYSHLRGTHL KTSTSLFYVN
3241: DVILPVLTAM FDHLAACEYG SDLLLDEIQV ASYKILQSLF TLGIDSSLTH DRKYLKTEIE
3301: RHRPALGTCL GAFSSTFPVA FLEPHLNKHN QFSLLNRIAD HSLEAQDIMA RMESSMPTLE
3361: TILGEVDQFV ESGKSHGDAP HVIDVILPLL CSYLPVWWAQ GPDNVNLTAD NHVTMVTSEH
3421: MNQLLKNVLN MIKKNIGNDN APWMTRIAAY TQQIIINSSE ELLKDPFLPL AERVKRRTDN
3481: LFHKEESLRG FIKSATDDTS QVETQIQEDW SLVVRDIYAF YPLLIKYVDL QRNHWLRNNI
3541: PEAEDLYNHI SEIFNIWSKS QYFLREEQNF ISANEIDNMI LIMPTATRRS ASAVTEGTAS
3601: GGRGKKKKKH RDKKRDMDKE LQASLMVACL KRLLPVGLNL FAGREQELVQ HCEDRFLKKL
3661: PEYEIMDFVK PQLTLPDKID PADEMSWQRY LYSKLGSKKD SGEVAKPQQI DEVVDRIVAM
3721: AKVLFGLHMI DHPQLQSKAV YRSVVSTQRK RAVIACFRQL SLHALPRHRA VNIFGRTYRE
3781: LWLQDENVGQ EVMIEDLTQS FEEAELKKAD KEEDEGKPDP LTQLVTTFCR GAMTERSGAL
3841: QEDPLYMSYA EIIAKSCGEE EEEGGEEEGE EAPEGEEGGS GSIHEQEMEK QRLLFNQSRL
3901: ADRGVAEMVL LHISACKGVP SEMVMKTLNL GIAVLRGGNS DIQMGMLNHL KEKKDVGFFT
3961: SIAGLMNSCS VLDLDAFERN TKAEGLGVGL EGAAGEKNMH DAEFTCTLFR FIQLTCEGHN
4021: LEWQNYLRTQ AGNTTTVNVV ICTVDYLLRL QESIMDFYWH YSSKELIDPA GKANFFKAIG
4081: VASQVFNTLS EVIQGPCTQN QQALAHSRLW DAVGGFLFLF SHMQDKLSKH SSQVDLLKEL
4141: LNLQKDMITM MLSMLEGNVV NGTIGKQMVD TLVESASNVE LILKYFDMFL KLKDLTSSAS
4201: FLEIDPNNEG WVLPKDFKEK MEQQKSYTPE EIEFMLACCE TNHDGKIDYV GFTDRFHEPA
4261: KEIGFNLAVL LTNLSEHMPN EPRLARFLET AGSVLNYFEP FLGRIEILGG SKRIERVYFE
4321: IKESNIEQWE KPQIKESKRA FFYSIVTEGG DKEKLEAFVN FCEDAIFEMQ HASGLMAVDD
4381: GSGVGGGKTR KAAYSYLTDD DEEKNVHPVK RGLQAVKDTI FFIFAMLSPS NIKHKMGELQ
4441: QMSAPEMVVG FFKLFFYLFY YSGFSVMVVF RYFARILMTL MRGPQVEEPV VEVKEEEKWG
4501: SMKKLPALPS PEDSKDSQTE GSKEDGGHDK ASHEGTPSGR QLSTDEGGDS PTGESGDSHS
4561: RSDSDEAAKA EGALTLTEFL GLDHSSEDSG GAAKKEAALV AEVAAQHQAV MAAVEAEGKQ
4621: ETVAEPSAFS QIDFNGYTHR ALSFLARNFY NLKYVALVLA FCINFILLFY KVTVIGGDEE
4681: DGGSGDDFGG ISGEDLLGMD GGSGDDGGGS GEDEEEPLEI VHVDEDFFYM YHVLRIAAFV
4741: HSLVSLAMLI AYYHLKVPLA IFKREKEIAR RLEFDGLFIA EQPSDDDIKS HWDKLVISAK
4801: SFPVNYWDKF AKKKVRQKYS ETYDFDSISN LLGMEKTSFS SQENEEGSGV INFILNIDWR
4861: YQMWKAGVTI TDNAFLYSLW YFTFSILGNF NNFFFAAHLI DVAVGFKTLR TILQSVTHNG
4921: KQLVLTVMLL TIVVYLYTVI AFNFFRKFYV TEEDDNVDMK CHNMLTCFVF HLYKGVRAGG
4981: GIGDEIEPPD GDDYEVYRIM FDITFFFFVI IILLAIIQGL IIDAFGELRD QLESVKEDME
5041: SNCFICGIGK DYFDKVPHGF DTHVQQEHNL ANYMFFLMHL INKPDTEYTG QETYVWNMYQ
5101: QRCWDFFPVG DCFRKQYEEE LGGGGG