1.A.3.2.16
Inositol triphosphate receptor, IP3R, also called Itr-1, Dec-4 and Ife-1, of 2892 aas and 6 TMSs (Baylis and Vázquez-Manrique 2012). Receptor for inositol 1,4,5-trisphosphate, a
second messenger that regulates intracellular calcium homeostasis.
Binds in vitro to both 1,4,5-InsP3 and 2,4,5-InsP3 with high affinity and does
not discriminate between the phosphate at the 1 or 2 position. Can also bind
inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol
4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a
timekeeper/rhythm generator via calcium signaling, affecting the
defecation cycle and pharyngeal pumping (Dal Santo et al. 1999). Affects normal hermaphrodite
and male fertility as a participant in intracellular signaling by acting
downstream of let-23/lin-3 which regulates ovulation, spermathecal
valve dilation and male mating behavior (Walker et al. 2002; Gower et al. 2005). Important for early embryonic
development; controls epidermal cell migration and may also regulate
filopodial protrusive activity during epithelial morphogenesis (Thomas-Virnig et al. 2004; ).
Component of inositol trisphosphate (IP3)-mediated downstream signaling
pathways that controls amphid sensory neuronal (ASH)-mediated response
to nose touch and benzaldehyde (Walker et al. 2009).
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| Accession Number: | Q9Y0A1 |
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| Protein Name: | Inositol 1,4,5-trisphosphate receptor itr-1 |
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| Length: | 2892 |
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| Molecular Weight: | 330837.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium(2+) |
|---|
1: MNPSYGRVRK KVSIISIPEF VPEHYEYENE TTASGGASGG GSTRIEFDFD DFEEQIMRKS
61: SMALPSRKLT IANSIDHGNN GNLHIGDIIS LYTESSSNQE QRGFLSTLGL VDDRCIVELK
121: DGRPESPPKK FRDCLFKVCP VNRYAAQKHL WTEQKRFQTG DSMFDDDLMN KLKVAADKER
181: EENESEFQKT LGNVIQYGSM VQLLHVKSNK YITVQKNSPA KRERNAMKVY LDRAGNEGSW
241: FIIEPAYKHY AIGDNVSAGN KISLIPNSVS TTQAGHVKSQ LHLSSFNLLD HQSAAEVNCL
301: NEPTEWQVFM FLLFDENQQN SVKSGDVVRL FHADQQTFLT LDTIPKQNPP TDVVFLRMTN
361: RPSAADATSS RALWEVQVVQ TNAYRGGTAK WNKAYRFKHL ATDMYLSAEP SQVQVKPAMN
421: GRRASLIYSK TNNPMAMYSD GPNGVTNEST DTTQQNIPSV WVLGPTKSEF PEEDANLLFQ
481: LDPSTFMKSN KEVPRRSYVR LLHQSSDKWV HATNATEKQN LHYSSKNEKG WVKVICEKNR
541: VDKETFALLP VNPDEVRDLD FANDACKALR NFIKLIKIGQ VISKESINST TQLLIDCILF
601: VTNSSDHLAD PLKISDFSPS RDRQKLLREQ EVLNQVFLLL KAPFLPRQGT TELGPLLSSP
661: SELSDSRNEI FKTMFQLCYC LLKYSQVSYR KNQEFLAEKF GEIQEQIGFD LMAEDTMTAV
721: LHNNPKLLEK YVKTPHVERF VELVRNNRQG KFLDYLADLC VCRGEANKKI QELICTSVLS
781: SKHRDIFMDT KIIDGEIEVG WAPNFRKLVD IAEGAKSNSD DAEHLDYYRH QLDLLSQMCQ
841: EQQYLAIDPP PERRLMNISQ QLPAELVLQC MSDNRLPYDL RGSFTRLMLH LHVVRGSPMS
901: AIRHARLWWS IPENVNVSTY ESVSVEAYSD GSRMRIGEGI AHKVLATVET YLMGLRNQSM
961: EERQSVNSSK LTYEIVNLAK ALAQFNFYSF NDLLQLTQNL LAIINEGPAT EQVPSHRAMV
1021: NAIRNMSKSM MRGGNKENSK DLAKTPSVTA EEAGRTKEGR ALNVKTKLIV AEILQFVMDV
1081: RRDYRITMAL SWFKNVFPCD EDGSLMHSAS INERMASELY DAIYRSSGHE LHLDGRDGQL
1141: LLAILLQMTM SDYPPLTSIA LKVFFRHFTQ YQELLEDLKQ VQLLVSNNDV ENYRQIDRDL
1201: FILKNLTEKS ELWVHGDRHH SIDTKEVDEK ERTTEHDLLD HDLKSPRAFD SGDSMEALMA
1261: VLNEHYPSIR NECLQLLNRL LIKDDRNDAA VALQELSDKA PLIAYPLIRQ MLVRLTGMCY
1321: RKGDPKPDTM NQQLLKNMRV YEVVLEFISV PHDKKHDHDM MKLITLSHEF LRSFCKTNKE
1381: NQSRLYKFIS YEKDAKEGML RVETIEEVGT LVAIFRNNRE LASNVPEELI AHIVGLIEHN
1441: SRNPIFLELL QALVCVYDKE IESGQEKVAN EICAASDEVR QLYVDNASFE ELEAMMKDEK
1501: ESKGRSSDSR RKLKYHIELV RLLAMCTRGK NGNTELKCAS QIPMDHIVRV VTAKQCLVEV
1561: KTVYLQLLLH CYIDTDAEMK DAYKTEYVDH ILNNLLEDIR SLRVEKLTGA ETATLEHYIC
1621: HTVTEVLIKF FEAPYSALQQ AKVDVHHHKK TFSEVLLELT YLEKGKLRGS KSSRNWYRVA
1681: ECIKRLTKWA EEHNITLPAT LAGPQMSGQT SVRQKWQQAA SSAKWIGIGK RLNRQNTLNP
1741: GHRLYGTSNS MTEHTSANVV TCYHMMIGEF KFYLHPLHAA EGSVLVEVLH TPELLFPEGS
1801: ALRDQCARGG VVAKLIQHCK TLMQNKQDNL CARVLQTLCK MCDCTKQQLT HQGQQLRQLL
1861: LQRYFGHHNN HHPPLDRQQS KIGEVIEAVK EKKEETWSQE RDLYAIQCKL NDAGASDLVT
1921: DIIIMEPSRE IFLKAIHLAR ALLHEGNDKV QHSFYMRMKQ KDIHEPFFKA ILTRIQTAQN
1981: RLKSDMMSCS DSKPKVSLSA TVSRRSSTVL TPLIDAGDTG FNGALFEVPQ QVRHPSISEM
2041: SQLSNDLTHS IPDLAPYQDE EKSTDALPPE VALVEPILRV LQLLCENHNS LLQNFLRKQS
2101: DRTNHNLVSE TLSFLDTVCG STKGSLGVFG EIGEHNFSLI TQTLATLTEF CQGPCHENQN
2161: TMAMQENGLN IIISLVLNEI KPLADDHMEL ALEIKSQASK LLLAIMESRH DGENANRVLR
2221: NMANMSGGPK QLVHAIKQAY EMTNSNHHML KSISRDLFRQ AEDDLKKKSG PQITVNTVTL
2281: PEINVDASGI VSIHTEKNIS SSLDDKFNDD DIPSVDPREV GHNIYILAHQ LAIHDGELEI
2341: WLDGSDEKKD DLTREALNYY KERTAQIEIV RRDRTLERVV FPINDICSYL TKDTKDYVYN
2401: NTERDNQGSK VTEFFDEWET MYHEMIWQRK LQDRKWLSWC AFRLPLWTRL SFHFAFIVNA
2461: LVARYYPLPE HSNSSISLGN LYSWFAVFSS FLLAHYLRHD KIYLHKTSLL ILASLCFLLL
2521: SSIGVTLTLY IFGILQLVNK IVHVVAFVSN KGLEDRPIAE ILACRNLHYL LVYLFICILG
2581: LLVHPMIYCI LLFDIIFTEE TLQNVIASVT RNYQSIVWTG LLALILLYFF SILGFLYFRH
2641: DFYLEVDPVE NDSSATISSG IPSETCPSEG CPGLQPSEKD DNDDEKKVKS CETLWMCILQ
2701: TGYQGLRNGG GIGDVLRNPA PWEDMFIWRV AYDMTFFVVL IVIVLNLIFG VIIDTFGDLR
2761: AEKNEKEQIL KNNCFICGLD RSRFDNRSVT FETHRETEHN IWHYLYYIVM LQIKDETEFT
2821: GPESYVAQCV KDRNLDWFPR MQALSLQDSE LDTDQSEVKQ MKDQLLQMMT LMREIISQNE
2881: ESRAFMEQFQ PR