| |
|---|---|
| Accession Number: | P29993 |
| Protein Name: | Inositol 1,4,5-trisphosphate receptor |
| Length: | 2838 |
| Molecular Weight: | 319107.00 |
| Species: | Drosophila melanogaster (Fruit fly) [7227] |
| Number of TMSs: | 6 |
| Location1 / Topology2 / Orientation3: | Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
| Substrate | calcium(2+) |
Cross database links:
| RefSeq: | NP_730941.1 NP_730942.1 |
|---|---|
| Entrez Gene ID: | 40664 |
| Pfam: | PF08709 PF00520 PF02815 PF08454 PF01365 |
| KEGG: | dme:Dmel_CG1063 |
Gene Ontology
GO:0005789
C:endoplasmic reticulum membrane
GO:0016021
C:integral to membrane
GO:0005220
F:inositol 1,4,5-trisphosphate-sensitive calc...
GO:0007629
P:flight behavior
GO:0007591
P:molting cycle, chitin-based cuticle
GO:0016319
P:mushroom body development
GO:0000280
P:nuclear division
GO:0051209
P:release of sequestered calcium ion into cyt...
GO:0006979
P:response to oxidative stress
GO:0007608
P:sensory perception of smell
GO:0030322
P:stabilization of membrane potential
GO:0055085
P:transmembrane transport
GO:0007601
P:visual perception
| |
References (5)[1] “Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster.” Yoshikawa S.et.al. 1322910 [2] “Sequencing and exon mapping of the inositol 1,4,5-trisphosphate receptor cDNA from Drosophila embryos suggests the presence of differentially regulated forms of RNA and protein.” Sinha M.et.al. 10375644 [3] “The genome sequence of Drosophila melanogaster.” Adams M.D.et.al. 10731132 [4] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.” Misra S.et.al. 12537572 [5] “Drosophila homologs of two mammalian intracellular Ca(2+)-release channels: identification and expression patterns of the inositol 1,4,5-triphosphate and the ryanodine receptor genes.” Hasan G.et.al. 1338312
| |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MGDNIIGSAS FLHLGDIVSL YAEGSVCGFL STLGLVDDRT VVCPEAGDLS CPPKKFRDCL 61: IKICPMNRYS AQKQFWKAAK QSASSNTDPN LLKRLHHAAE IEKKQNETEN KKLLGTSIQY 121: GRAVVQLLHL KSNKYLTVNK RLPSLLEKNA MRVYLDANGN EGSWFYIKPF YKLRSIGDYV 181: VVVGDKVILS PVNADQQNLH VAANYELPDN PGCKEVNVLN SSTSWKISLF MEHKENQEHI 241: LKGGDVVRLF HAEQEKFLTM DEYKKQYHVF LRTTGRTSAT AATSSKALWE IEVVQHDSCR 301: GGAGDWNSLY RFKHLATGHY LAAEAEIDVS AGAMSATSAS GHDLHLGDCS KDSGLSCSTM 361: NSTINDKPKG KQYRLVSVPY SADIASVFVL DATTMARPDS LVPQSSYVRL QHICSNTWVH 421: ATSIPIDADD DKPVMSMVCC SPIKEDKEAF ALIPVSPVEV RDLDFANDAC KVLATVTSKL 481: DNGSISINER RALISLLQDI VYFIAGMENE QNKTKALEFT IKNPIRDRQK LLREQYILKQ 541: LFKILQGPFQ EHTAGDGPFL RLDELSDPKN SPYKNIFRLC YRILRLSQQD YRKNQEYIAK 601: HFGLMQKQIG YDILAEDTIT ALLHNNRKLL EKHITAAEIE TFVGLVRKNM HNWDSRFLDY 661: LSDLCVSNRK AIAVTQELIC KSVLSDKNKD ILIETQVKAL RTGSGPVRCY KGNSEDVCLA 721: TLAEDPGDDE DRSDVQSTST TTTWDSASLN EDDGTPSTGD KYEIHLKWTG QPTSRSMADL 781: ASCDGGELEA AILNYYRHQL NLFSNMCLNR QYLALNELSP RLDIDLILKC MSDETMPYEL 841: RASFCRLMLH LHVDRDPQEP VTPVKYARLW SEIPSKMSIQ DYDGKNQQPD QNKQACRAKF 901: NTTIAFVENY LCNVATKVWL FTDQEQNKLT FEVVKLARDL IYFGFYSFSD LLRLTKTLLS 961: ILDCVSDTSS GEFASTDIDS VEEETNAEAE GGVLRSIGDI NTVMTSLALG SVGQAIAAPT 1021: ISLQQRKSVS QLMKEYPLVM DTKLKIIEIL QFILDVRLDY RISCLLSIFK REFDESEVAA 1081: SAASNEASQQ QSQQQEPQTP GSSNETDPLD SAESVAAGAA AAAATTARQK NIDLESIGVQ 1141: AEGIFDCERS DAANLDLDGQ GGRTFLRVLL HLIMHDYAPL VSGALHLLFR HFSQRQEVLQ 1201: AFRQVQLLVS DSDVESYKQI KSDLDILRQS VEKSELWVYK AKATDELGAT DAGGDAVSLE 1261: YNAALSQEQR NEYRKVKEIL IRMNKFCVTA SGPGSVVKPR KHEQRLLRNV GVHTVVLDLL 1321: QNPYDEKDDE LMKELMCLAH EFLQNFCLGN QQNQVLLHNH LDLFLNPGIL EAKTVCAIFK 1381: DNLALCNEVT DKVVQHFVHC IEIHGRHVAY LQFLQTVVAA ENQFIRRCQD MVMQELINSG 1441: EDVLVFYNDK GSFNHFVQMM QQQMLGMEKL SDDSPLKYHV ELVKLLACCT MGKNVYTEIK 1501: CNNLLSLDDI VTIICHPLCM PEVKEAYVDF LNHCYIDTEV EMKEIYASGH MWSLFEKSFL 1561: VDINQLITNP AAASNKTLQA YVLNGVTNLL GSFFASPFSD QSAIVQSRQL IFVQLLQAAH 1621: RITQCRWLSL GDRFNVENCI RTLTESAKMR SIALPPELEQ QVATMSSKTA MLTRQTTKWL 1681: LASKQPKYEA QQAASLMRWD RSIIEGLQDI VSLLEDQLKP VVEAELSLLV DILYRSELLF 1741: PAGTEARKRC ESGGFIRKLI KHTEKLLEEK EERMCVKVLR TLREMMAIDV NYGEKGDALR 1801: QTLLLRYFQT KSTPRLPEDE VPLLAAPLMD PAKQNHLVTH GPGAKYLQRA GKTLHEMQNH 1861: LDREGASDLV VELVIKSVHS PNIFVEAVEL GIALLEGGNP IIQKGMFQKF LSDDLNQAFF 1921: KVFFEKMKDA QQEIKSTVTV NTTDIAAKAH EHKQDTNLEL DKIARKHGLK SNGVVITEEL 1981: KRELHNAGLA TARAYGNARN IHSGEESSAI SVNSPLEDIL AEKLEKHKDS RDQRNQLSNK 2041: VLVMQPILRF LQLLCENHNP DMQNLLRNQN NKTNNNLVSE TLMFLDCICG STTGGLGLLG 2101: LYINEHNLAL INQTLEALTE YCQGPCHENQ NCIATHESNG LDIITALILN NINPLGENRM 2161: DLVLELKNNA SKLLLAIMES RGDSENAERI LYNMNPKQLV EVACKAYHQE ELIDEQDDGD 2221: EPDAGSDDDD ATVSPREVGH NIYILCHQLA QHNKELAGLL KASEDPQSAS FDAKTSQALM 2281: YYATHTAQIE IVRNDRTLEQ IVFPIPEICE YLTTDTKIKI LNTAERDDQG SKLADFFDKA 2341: EEMFNEMKWQ KKLRSQPLLF WISSYMSLWS NILFNCVVVI NMIVAFFYPF DNTVPELSSH 2401: ISLLFWIITI FSLVIVLALP RESGIRTFIG SVILRFIFLL GPESTLCLLG VVTVTLKSVH 2461: IVSIMGNKGT LEKQLIKIIT DFQLLYHCIY IAFCFCGLIF HPFFYSLLLF DVVYREETLV 2521: NVIRSVTRNG RSIVLTAVLA LILVYLFSII GYMFFKDDFL VSVDFEEQDN APPPSVPLTL 2581: SVPVSGDSCS APDDLGNCQA AKEVAPPSAG GGEVKERSCD SLVMCIVTTL NQGLRNGGGI 2641: GDILRAPSSK EGLFVARVIY DLLFFFIVII IVLNLIFGVI IDTFADLRSE KQQKEAILKT 2701: TCFICSLNRS AFDNKTVSFE EHIKSEHNMW HYLYFIVLVK VKDPTEFTGP ESYVYAMVKA 2761: GILEWFPRLR AMSLAAVDAD GEQIELRSMQ AQLLDTQLLI KNLSTQLHEL KDHMTEQRKQ 2821: KQRLGLLNTT ANSLLPFQ