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| Accession Number: | Q63269 |
| Protein Name: | Inositol 1,4,5-trisphosphate receptor type 3 |
| Length: | 2670 |
| Molecular Weight: | 304286.00 |
| Species: | Rattus norvegicus (Rat) [10116] |
| Number of TMSs: | 6 |
| Location1 / Topology2 / Orientation3: | Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
| Substrate | calcium(2+) |
Cross database links:
| Entrez Gene ID: | 25679 |
|---|---|
| Pfam: | PF08709 PF00520 PF02815 PF08454 PF01365 |
| KEGG: | rno:25679 |
Gene Ontology
GO:0045177
C:apical part of cell
GO:0005903
C:brush border
GO:0005789
C:endoplasmic reticulum membrane
GO:0043209
C:myelin sheath
GO:0043025
C:neuronal cell body
GO:0005640
C:nuclear outer membrane
GO:0015085
F:calcium ion transmembrane transporter activity
GO:0043533
F:inositol 1,3,4,5 tetrakisphosphate binding
GO:0005220
F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0000822
F:inositol hexakisphosphate binding
GO:0005218
F:intracellular ligand-gated calcium channel activity
GO:0060402
P:calcium ion transport into cytosol
GO:0007186
P:G-protein coupled receptor signaling pathway
GO:0051291
P:protein heterooligomerization
GO:0051260
P:protein homooligomerization
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References (3)[1] “Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues.” Blondel O.et.al. 8388391 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC 61: PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS 121: VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG 181: DKVILNPVNA GQPLHASNYE LSDNVGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV 241: VRLFHAEQEK FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 301: NGLYRFKHLA TGNYLAAEEN PSYKGDVSDP KAAGPGAQSR TGRRNAGEKI KYRLVAVPHG 361: NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNAPIDVEEE RPIRLMLGTC 421: PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV 481: FFVSDVPNNG QNVLDIMVTK PNRERQKLMR DENILKQIFG ILKAPFRDKG GEGPLVRLEE 541: LSDQKNAPYQ YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 601: NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NRIAIPVTQE LICKCVLDPK 661: NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN NEHHEKSVRQ LAQEARAGNA 721: HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISKQLGVELL FLCMADEMLP FDLRASFCHL 781: MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY 841: LNNVVGEAVP FANDEKNILT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCIQAPAA 901: VLQAYEEPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGASS LPTGVGVPEQ LDRSKFEDNE 961: HTVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSST 1021: ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRMFLRVLL HLTMHDYPPL VSGALQLLFK 1081: HFSQRQEAMH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSVKGEEGE 1141: AGASKDKKER PSDEEGFLQP HGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM 1201: DAHKVMLDLL QIPYDKNDNK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL QLFLTPGLLE 1261: AETMQHIFLN NYQLCSEISE PVLQHFVHCW PTHGRHVQYL DFLHTVIKAE GKYVKKCQDM 1321: IMTELTNAGD DVVVFYNDKA SLAHLLDMMK AARDGVEDHS PLMYHISLVD LLAACAEGKN 1381: VYTEIKCTSL LPLEDVVSVV THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL 1441: FENFTLDMAL VCNKREKRLS DPTLEKYVLT VVLDTISAFF SSPFSENSTS LQTHQTIVVQ 1501: LLQSTTRLLE CPWLQQQHKG SVEACVRTLA MVAKSRAILL PMDLDAHMSA LLSSGGSCSA 1561: AAQRSAANYK TATRTFPRVI PTANQWDYKN IIEKLQDIIT ALEERLKPLV QAELSVLVDM 1621: LHWPELLFLE GSEAYQRCES GGFLSKLIRH TKGLMESEEK LCVKVLRTLQ QMLQKKSKYG 1681: DRGNQLRKML LQNYLQNRKS GPRGELTDPT GSGVDQDWSA IAATQCRLDK EGATKLVCDL 1741: ITSTKNEKIF QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET 1801: KSTVAVNMSD LGSQPREDRE PADPTTKGRV SSFSMPSSSR YSLGPGLHRG HDVSERAQNN 1861: EMGTSVLIMR PILRFLQLLC ENHNRDLQNF LRCQNNKTNY NLVCETLQFL DIMCGSTTGG 1921: LGLLGLYINE DNVGLVIQTL ETLTEYCQGP CHENQTCIVT HESNGIDIIT ALILNDISPL 1981: CKYRMDLVLQ LKDNASKLLL ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN 2041: SEVSPREVGH NIYILALQLS RHNKQLQHLL KPVKRIQEEE AEGISSMLSL NNKQLSQMLK 2101: SSAPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP AICQFLTEET KHRLFTTTEQ 2161: DEQGSKVSDF FDQSSFLHNE MEWQRRLRSM PLIYWFSRRM TLWGSISFNL AVFINIIIAF 2221: FYPYVEGAST GVLGSPLISL LFWILICFSI AALFTKHYSV RPLIVALVLR SIYYLGIGPT 2281: LNILGALNLT NKIVFVVSFV GNRGTFIRGY KAMVMDMEFL YHVGYILTSV LGLFAHELFY 2341: SILLFDLIYR EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR 2401: LPGNHSRAST LGMPHGAATF MGTCSGDKMD CVSEVSVPEI LEEDEELDST ERACDTLLMC 2461: IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF FIVIIIVLNL IFGVIIDTFA 2521: DLRSEKQKKE EILKTTCFIC GLERDKFDNK TVSFEEHIKL EHNMWNYLYF IVLVRVKNKT 2581: DYTGPESYVA QMIKNKNLDW FPRMRAMSLV SGEGEGEQNE IRILQEKLGS TMKLVSHLTA 2641: QLNELKEQMT EQRKRRQRLG FVDVQNCMSR