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| Accession Number: | Q14643 |
| Protein Name: | Inositol 1,4,5-trisphosphate receptor type 1 |
| Length: | 2758 |
| Molecular Weight: | 313945.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 6 |
| Location1 / Topology2 / Orientation3: | Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
| Substrate | calcium(2+) |
Cross database links:
| DIP: | DIP-29714N |
|---|---|
| Entrez Gene ID: | 3708 |
| Pfam: | PF08709 PF00520 PF02815 PF08454 PF01365 |
| KEGG: | hsa:3708 |
Gene Ontology
GO:0005789
C:endoplasmic reticulum membrane
GO:0016021
C:integral to membrane
GO:0031088
C:platelet dense granule membrane
GO:0031095
C:platelet dense tubular network membrane
GO:0015085
F:calcium ion transmembrane transporter activity
GO:0005220
F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005218
F:intracellular ligand-gated calcium channel activity
GO:0035091
F:phosphatidylinositol binding
GO:0007202
P:activation of phospholipase C activity
GO:0008219
P:cell death
GO:0006112
P:energy reserve metabolic process
GO:0007173
P:epidermal growth factor receptor signaling pathway
GO:0008543
P:fibroblast growth factor receptor signaling pathway
GO:0048011
P:nerve growth factor receptor signaling pathway
GO:0030168
P:platelet activation
GO:0050796
P:regulation of insulin secretion
GO:0001666
P:response to hypoxia
GO:0044281
P:small molecule metabolic process
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References (16)[1] “Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization.” Yamada N.et.al. 7945203 [2] “The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation.” Harnick D.J.et.al. 7852357 [3] “Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant.” Nucifora F.C. Jr.et.al. 7500840 [4] “The DNA sequence, annotation and analysis of human chromosome 3.” Muzny D.M.et.al. 16641997 [5] “Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation.” Yan J.et.al. 8648241 [6] “Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.” Yang J.et.al. 12032348 [7] “Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.” Kasri N.N.et.al. 14685260 [8] “Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44.” Higo T.et.al. 15652484 [9] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [10] “IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.” Antl M.et.al. 16990611 [11] “Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans.” van de Leemput J.et.al. 17590087 [12] “Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.” Wang B.et.al. 19007248 [13] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976 [14] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [15] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [16] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332
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| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP KKFRDCLFKL 61: CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV 121: IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD 181: KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV 241: RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 301: SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE 361: GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT 421: SPVKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL 481: VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE 541: LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 601: NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT 661: NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF WRDSNKEIRS KSVRELAQDA 721: KEGQKEDRDV LSYYRYQLNL FARMCLDRQY LAINEISGQL DVDLILRCMS DENLPYDLRA 781: SFCRLMLHMH VDRDPQEQVT PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF 841: VEEYLRDVVC QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH 901: VTTIFPISKM AKGEENKGNN DVEKLKSSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA 961: PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQTSE 1021: TSSGNSSQEG PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH 1081: DYPPLVSGAL QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE 1141: LWVYKGQGPD ETMDGASGEN EHKKTEEGNN KPQKHESTSS YNYRVVKEIL IRLSKLCVQE 1201: SASVRKSRKQ QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ 1261: NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK 1321: FLQTIVKAEG KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP 1381: LMYHIHLVEL LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HEDCIPEVKI AYINFLNHCY 1441: VDTEVEMKEI YTSNHMWKLF ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF 1501: SSPFSDQSTT LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS DVAKSRAIAI 1561: PVDLDSQVNN LFLKSHSIVQ KTAMNWRLSA RNAARRDSVL AASRDYRNII ERLQDIVSAL 1621: EDRLRPLVQA ELSVLVDVLH RPELLFPENT DARRKCESGG FICKLIKHTK QLLEENEEKL 1681: CIKVLQTLRE MMTKDRGYGE KLISIDELDN AELPPAPDSE NSTEELEPSP PLRQLEDHKR 1741: GEALRQVLVN RYYGNVRPSG RRESLTSFGN GPLSAGGPGK PGGGGGGSGS SSMSRGEMSL 1801: AEVQCHLDKE GASNLVIDLI MNASSDRVFH ESILLAIALL EGGNTTIQHS FFCRLTEDKK 1861: SEKFFKVFYD RMKVAQQEIK ATVTVNTSDL GNKKKDDEVD RDAPSRKKAK EPTTQITEEV 1921: RDQLLEASAA TRKAFTTFRR EADPDDHYQP GEGTQATADK AKDDLEMSAV ITIMQPILRF 1981: LQLLCENHNR DLQNFLRCQN NKTNYNLVCE TLQFLDCICG STTGGLGLLG LYINEKNVAL 2041: INQTLESLTE YCQGPCHENQ NCIATHESNG IDIITALILN DINPLGKKRM DLVLELKNNA 2101: SKLLLAIMES RHDSENAERI LYNMRPKELV EVIKKAYMQG EVEFEDGENG EDGAASPRNV 2161: GHNIYILAHQ LARHNKELQS MLKPGGQVDG DEALEFYAKH TAQIEIVRLD RTMEQIVFPV 2221: PSICEFLTKE SKLRIYYTTE RDEQGSKIND FFLRSEDLFN EMNWQKKLRA QPVLYWCARN 2281: MSFWSSISFN LAVLMNLLVA FFYPFKGVRG GTLEPHWSGL LWTAMLISLA IVIALPKPHG 2341: IRALIASTIL RLIFSVGLQP TLFLLGAFNV CNKIIFLMSF VGNCGTFTRG YRAMVLDVEF 2401: LYHLLYLVIC AMGLFVHEFF YSLLLFDLVY REETLLNVIK SVTRNGRSII LTAVLALILV 2461: YLFSIVGYLF FKDDFILEVD RLPNETAVPE TGESLASEFL FSDVCRVESG ENCSSPAPRE 2521: ELVPAEETEQ DKEHTCETLL MCIVTVLSHG LRSGGGVGDV LRKPSKEEPL FAARVIYDLL 2581: FFFMVIIIVL NLIFGVIIDT FADLRSEKQK KEEILKTTCF ICGLERDKFD NKTVTFEEHI 2641: KEEHNMWHYL CFIVLVKVKD STEYTGPESY VAEMIKERNL DWFPRMRAMS LVSSDSEGEQ 2701: NELRNLQEKL ESTMKLVTNL SGQLSELKDQ MTEQRKQKQR IGLLGHPPHM NVNPQQPA