1.A.3.2.9
CRCI-1a; IP3R. Functions similarly to TC# 1.A.3.2.7 (Docampo et al. 2013). Cortical Ca2+ stores
(alveolar sacs) are activated during stimulated trichocyst exocytosis, mediating store-operated Ca2+ entry (SOCE). Ca2+ release channels (CRCs) localise to alveoli and are Ryanodine receptor-like proteins (RyR-LPs) as well as inositol 1,4,5-trisphosphate receptors (IP3Rs), members of the CRC family with
6 subfamilies (Plattner 2014).
|
| Accession Number: | G7ZU97 |
|---|
| Protein Name: | Calcium-release channel I-1a |
|---|
| Length: | 2972 |
|---|
| Molecular Weight: | 348963.00 |
|---|
| Species: | Paramecium tetraurelia [5888] |
|---|
| Number of TMSs: | 6 |
|---|
| Substrate |
calcium(2+) |
|---|
1: MNQEDLNYLT YGSVISISHV QDDHSFITAD GFVKRAVCLQ NFHHIDVVDV KQLGKMKSRP
61: YYHTLFQIFP KFTNTTKQEI LKELIGEEQE EEVQPAVQNI LESISKHQKV DEKTILSKEQ
121: VQMFSQKLLQ EFKYNLDTFE KSKAHKVSYK SHIQLLHLAS SKFLACHQKE ARVESSNYKI
181: TLDELPSDSS LFKILPAYKY QKEGEQVIYA SDIVYIVRAT SFMNKLTFLH ASQEMGNYGK
241: SRKQKKSDED LLQYKMEKDI IKREVNAALD EENQTQWRIS VYSDYVPETS GYLKCGDVIW
301: LHHSETNTTI AATRKGKPVD QKNFQSFNLV DWLKVENVEL NVLSGSTKES YDEYTGDTHS
361: MWIIESEIYK EGGIVVFDKK YRFKHFTSGL YLSGIQDKFT LDKQRVPTTL FYFSQLKNSQ
421: VREKSVMRGS YVYICHDKPI PSGTINNQND ENSFWVDIQY GKYQRYIPIL HQEQHKTDQS
481: VFKLYASSSN DVWEISFVLS CAKTLTNYLD DLQKLKWEND AQDKEVLKDH LLKIQTTKQC
541: IEDINDFCNN RLYNSTPEQK YGTINPFRQK LLKEQYYIDL LVKILVQQLK PEDLVIWSRR
601: FMIIQMQDIQ QQQEKMSNTE QTNKKQGLKD HEILAYIAFK ITLNQTIYTL LTSICKQNPE
661: NELYTFDLIG HFLEHCRYIP EAIKCMISII GNNPELLQQL SLNMKLDYIP KEQDFFEPEE
721: EKMQLHHNKI QNNFLIFFLN LLETDEQAHK ADFLTFLREM CIYNSQGINS NQEAIYKLLK
781: KHNHKKIQLI KDREDPDKIS LKDGKLVIPF KLQNDPKEMY FINEQLQFYA DVSYGRNYLW
841: KQELEQYFSK DFLFQNIWQE DGNRTYAVLQ AALCKIAMSL YIDHDPLNKV QLPKYCNLFK
901: SIDKANEAQH MGLYTSLIED LFKYLQDNKQ QIVLALDTKD SGDNNKDYDM LEANDEKSLL
961: INELLYNSCQ MMLLVLELDV FLLLDKEPNQ YYKQIIDIVI HYFFYDFTQL PLMKSVYKVQ
1021: KSEITQRKER KEVNPLGIGL NLGANLISMA NPMNIGLNLN LFGSDEEQKS ESDDDEQIDE
1081: GIVDDVQMYT NPLMRGFIKL ENELQSTLLT REETGSSQLE IKIKLTLCDV MDRFLDMRQN
1141: YLMLNCLSFF KKQIIEKMQE GIQQLKFSKD DASQEQEETK ILIFVQRKTE SNLLGLMPNI
1201: AKTGLKEVDE KEEKQDAFGI GALNFLNKLA ETKPESEEFK VFTQNEMLIY DLDQYFSLNL
1261: PQEDISKINN PIGVVLPYLF TNFSQIHEEE LEKRCLAIIM RLFNQREELC NNLLKLQLVS
1321: DPIKSRLYEF LSENLQRLNQ LVDRSEVWLA EYIKSQKQDD LEETLEIIDN FRQGFFKDTQ
1381: ISSKIISGTQ EIDAEKQNLM NALKIHLPIL NLIRDQMSAL DFHLENIKNI QRKQRLAQLF
1441: IYAFQFLTYF CRNNHENQIV LSQYISYFEN MHLEVGQIPL ICEIYKDNQK LLTSINRNDR
1501: VFHKFVELIY QSGRKAQFLD FFLTIIKQGN KYIFDNQLLV LNTFLEKEEL LFTEKNEFVF
1561: EGDIQLHQSD FLTDLASNPP MNQPFLYHAK LLDLLLQCTQ IQVLEGDQKD NFTINVAKLK
1621: KKFSAQYMIQ LLCKPDSLCS RNPSLQEQGF GLIKKQLWIF FMNVHITSEK SQNFLKEIKN
1681: DLLNMIDFEI KRLEHIQFDH QQLRYFDFLI EAVIPLFTTY LIRKNISVHQ DEDEDGHDQE
1741: QKDIAAFQAF AKTLSSKILH LGKYVNRKKH VSVLIAFYSY FPLTIMGKVC QSVSGQSKLM
1801: EDLGEFNGFR DVLSNIQAGA NDNYQSDLNE QVIHLQSGIQ QSHGDHHTPK TIFQSNNVKS
1861: KIGIMSALSS NKKQKEEPLI EFESAEIEKI SGSWEEFVNQ LCLSDKSKNY VQDELQKLSE
1921: AIVKFEQYFG NPSDKNDKNE KILKVEYVIL LKKFINFLSY AINSSQNNKT IITLLGVLRK
1981: VIEGKPKEEQ KEKVEVEGEN NEMEDVQNLF NKLGATRMVL TVLSESIILD GEMLRNFLLF
2041: INTLLSGGNN KVQKTIFEFM KTYPKSEVIF SRLNNVIQAQ IKQITNKEKD KKTEEQQLGN
2101: LPSQQQEDNV QELKQQQDLE LLLTQVLKFL QNCCEGHYLD LQNYIRQQTN SRNSFNMINQ
2161: VAELLLTYYY KDRAQYENMV LCLDTLNELV QGPCPENQIA VADSKFFEIA SDLFGQKKEK
2221: DSTGKTQIMI SNIKTSKTQN NKMMTSKTGR YQKQQKGSDL KIWQIERMQT KCLILILSLI
2281: EMREISDSNP IIKRIMRHLT PPLLEKHMVS CFHKYEKQCK EGYQIEVLDR IKEDPESAKQ
2341: EDKVKEEQYY ELILQKGFYI YFLMSYYMES EKNVENSFVQ MYRANTRKKL KQDKGTLEDL
2401: LFGDNIIGQL VSFVMSFANS WIDLMNQIKK EAQKQMATQA QTSEQQEKQD RERRAEKEKM
2461: KRRAFDFFYK NSASIEVVRN NEIEIVYFLL LPYTHNLPKE QKVEFHENVD RSSTKSKVQF
2521: LVQESERLTE ICEHEEQLRR IFQRQKFLAL FANYVKLWKD LAFLFTLLLN LFIIGSFAQN
2581: ESGNRITDFR LFRDEQYSPQ QTRNIFLICG TIMACCSIFV VSFFLFKNAP LIIKKAWKTK
2641: LPFEDKFTYW PIQLIYKIFK LLAVLFYILK EIEVVYYLAY GALAVIGTVL HPFFFSFHLT
2701: EILIRYPTLK NVIRSVWEPK QQLGLTLVLF VILVYVYGLI AYTFFFEDYK GKCQSTLFCF
2761: LFTFDWTFKA NGGVGGYLSD LEDEDVVEKY RVSRFVFDNT SNIFLVIIMV NIVAGIIIDT
2821: FGSLREEESD KVRDIEDKCF ICGNLKTTFD RLTDTASMGG GFDHHIKVNH YMWNYVFFMA
2881: YLKYKDPTDY TGIEQFVWEK IQKKDLTWFP FNKARELQNI KQDEEEESKK IERISKDIVN
2941: IVDTMRQASQ MLNSIKNRKK LRNAAKQPAD ML