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1.A.4.1.6 Sperm TRP-3 (SPE-41) Ca²⁺-permeable channel. Translocated from vesicles to the plasma membrane upon sperm activation in a process dependent on the 4TMS SPE-38 protein (8.A.36.1.1) (Singaravelu et al., 2012) during sperm-egg interactions leading to fertilization (Xu et al., 2003).
Accession Number:	Q21070
Protein Name:	Putative uncharacterized protein spe-41 aka TRP3
Length:	854
Molecular Weight:	96937.00
Species:	Caenorhabditis elegans [6239]
Number of TMSs:	10
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	calcium(2+)

RefSeq:	NP_497709.1
Entrez Gene ID:	175446
Pfam:	PF00023 PF00520 PF08344
KEGG:	cel:K01A11.4
Gene Ontology GO:0016021 C:integral to membrane GO:0005216 F:ion channel activity GO:0006811 P:ion transport GO:0055085 P:transmembrane transport
References (2) [1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.” The C. elegans sequencing consortiumet.al. 9851916 [2] “A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization.” Xu X.Z.et.al. 12914694

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MVGKEKKEST RLKLSAIKEY LGKYRGVDAD NNEGYDGHQK WHENDQVVLQ AMAYFYKAVK 
61:	SKLYSEVRSF LGILLPHGPD DGRLSSLQSL LMDTSSEESL KEALLLSIAV GSRPLVEFVL 
121:	VLFVDAPYLE RSGSANSPHF PPHMTPLMLA CILNNFSIVQ CLITRGHCIQ IPHFITCECK 
181:	TCKRETVTTH SSTRLVDVMR ALSSEAYLWL ATDDVFAATC AVARDLQQLA SDDQLEYVET 
241:	YRDLEMNVQR FLCRISDQAW RVDEFNMMVA NRNYCPERMT EISSPRLQMA MDSQMRQFTC 
301:	STNSQTTIKS VFRSDWYNYG IKPKRDAWRF LRACILMPFL VMLHAFMPTK GTTMCVPLAR 
361:	FIAHITMYLV FLIAAILRPT IGFYFAWTDS IEVTVQALEI FMYAYVMGLA LEKGILFYRV 
421:	GRDGFFAFWW RWFDAALIFI FLFSLIFFTG KWGKREAFDP SSVDRMHWPS FEFSLLHEIC 
481:	LAIACVLSIL KCFYYAQMMK SIGGSVISVG KCVGKTYTYI LIMVAIIVSF SVGLNIIVDP 
541:	YLNRSTMKIG DQDYTKTTDS YETIGTSSKN LFWSIFGYLG PSTFTTVVGN TGPNMDPVKH 
601:	TLNSSTFEIL AAVYHGILII TVLNLMTSIL VKGADEVLDN EEMEFKFTRA AIYSEFLSWE 
661:	MAAPPPLNLI LVVAHFVHRN LLKRYYASPA WGEKPANDDV EDQAADEQYM QLLMVVFARF 
721:	VASKECKYKS IWRSEFHREE KQPPRVTFLT TGAHSFLMDN TFEGFKMRSS RTMEAEGYKE 
781:	YTTVQYYVPK SKTPGPAAAA DAGTKVAPKD DKPQNNPVLA RTGIDSPVPS SKQVMSSELS 
841:	ASIPRARDVT FLGV

1.A.4.1.6
Sperm TRP-3 (SPE-41) Ca²⁺-permeable channel. Translocated from vesicles to the plasma membrane upon sperm activation in a process dependent on the 4TMS SPE-38 protein (8.A.36.1.1) (Singaravelu et al., 2012) during sperm-egg interactions leading to fertilization (Xu et al., 2003).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

1.A.4.1.6Sperm TRP-3 (SPE-41) Ca2+-permeable channel. Translocated from vesicles to the plasma membrane upon sperm activation in a process dependent on the 4TMS SPE-38 protein (8.A.36.1.1) (Singaravelu et al., 2012) during sperm-egg interactions leading to fertilization (Xu et al., 2003).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

1.A.4.1.6
Sperm TRP-3 (SPE-41) Ca²⁺-permeable channel. Translocated from vesicles to the plasma membrane upon sperm activation in a process dependent on the 4TMS SPE-38 protein (8.A.36.1.1) (Singaravelu et al., 2012) during sperm-egg interactions leading to fertilization (Xu et al., 2003).