| |
|---|---|
| Accession Number: | P48994 |
| Protein Name: | Transient-receptor-potential-like protein |
| Length: | 1124 |
| Molecular Weight: | 127750.00 |
| Species: | Drosophila melanogaster (Fruit fly) [7227] |
| Number of TMSs: | 9 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | calcium(2+) |
Cross database links:
| Entrez Gene ID: | 36003 |
|---|---|
| Pfam: | PF00023 PF00520 PF08344 |
| KEGG: | dme:Dmel_CG1834 |
Gene Ontology
GO:0016027
C:inaD signaling complex
GO:0016021
C:integral to membrane
GO:0005622
C:intracellular
GO:0005516
F:calmodulin binding
GO:0046982
F:protein heterodimerization activity
GO:0015279
F:store-operated calcium channel activity
GO:0007589
P:body fluid secretion
GO:0019722
P:calcium-mediated signaling
GO:0071454
P:cellular response to anoxia
GO:0050908
P:detection of light stimulus involved in visual perception
| |
References (15)[1] “Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene.” Phillips A.M.et.al. 1314616 [2] “The genome sequence of Drosophila melanogaster.” Adams M.D.et.al. 10731132 [3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.” Misra S.et.al. 12537572 [4] “A Drosophila full-length cDNA resource.” Stapleton M.et.al. 12537569 [5] “Identification and characterization of two distinct calmodulin-binding sites in the Trpl ion-channel protein of Drosophila melanogaster.” Warr C.G.et.al. 8670063 [6] “Coassembly of TRP and TRPL produces a distinct store-operated conductance.” Xu X.-Z.S.et.al. 9215637 [7] “The role of calmodulin-binding sites in the regulation of the Drosophila TRPL cation channel expressed in Xenopus laevis oocytes by ca2+, inositol 1,4,5-trisphosphate and GTP-binding proteins.” Lan L.et.al. 9494079 [8] “Ca2+-dependent interaction of the trpl cation channel and calmodulin.” Trost C.et.al. 10371201 [9] “Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL.” Chyb S.et.al. 9930700 [10] “Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo.” Agam K.et.al. 10908615 [11] “Direct activation of trpl cation channels by G alpha11 subunits.” Obukhov A.G.et.al. 8918461 | |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MGRKKKLPTG VSSGVSHASS APKSVGGCCV PLGLPQPLLL EEKKFLLAVE RGDMPNVRRI 61: LQKALRHQHI NINCMDPLGR RALTLAIDNE NLEMVELLVV MGVETKDALL HAINAEFVEA 121: VELLLEHEEL IYKEGEPYSW QKVDINTAMF APDITPLMLA AHKNNFEILR ILLDRGAAVP 181: VPHDIRCGCE ECVRLTAEDS LRHSLSRVNI YRALCSPSLI CLTSNDPIIT AFQLSWELRN 241: LALTEQECKS EYMDLRRQCQ KFAVDLLDQT RTSNELAIIL NYDPQMSSYE PGDRMSLTRL 301: VQAISYKQKK FVAHSNIQQL LSSIWYDGLP GFRRKSIVDK VICIAQVAVL FPLYCLIYMC 361: APNCRTGQLM RKPFMKFLIH ASSYLFFLFI LILVSQRADD DFVRIFGTTR MKKELAEQEL 421: RQRGQTPSKL ELIVVMYVIG FVWEEVQEIF AVGMKSYLRN MWNFIDFLRN SLYVSVMCLR 481: AFAYIQQATE IARDPQMAYI PREKWHDFDP QLIAEGLFAA ANVFSALKLV HLFSINPHLG 541: PLQISLGRMV IDIVKFFFIY TLVLFAFACG LNQLLWYFAA LEKSKCYVLP GGEADWGSHG 601: DSCMKWRRFG NLFESSQSLF WASFGMVGLD DFELSGIKSY TRFWGLLMFG SYSVINVIVL 661: LNLLIAMMSN SYAMIDEHSD TEWKFARTKL WMSYFEDSAT LPPPFNVLPS VKWVIRIFRK 721: SSKTIDRQRS KKRKEQEQFS EYDNIMRSLV WRYVAAMHRK FENNPVSEDD INEVKSEINT 781: MRYEMLEIFE NSGMDVSSAN KKERQPRPRR IKVWERRLMK GFQVAPVQNG CELDAFGNVN 841: GQGEMQEIKV ESIPSKPAKE TAKERFQRVA RTVLLQSTTH KWNVVLRAAK DSQIGRCTKN 901: ERKSLQNLGR AIEEAKRLIM LNPGCPSGRE SPIRIEFEDE KTSTLLELLN QISAEISDSE 961: KPKIRPIWRP PLKTVPARAM AANNTRSLTA PELKISRKSS PAPTPTPTPG VSHTALSQFR 1021: NRELPLCPSK LIANSAPSAP TAPPKKSAPT APTPTYKPTT HAPFSVEGGN RENTRASDGV 1081: RSDNSNFDIH VVDLDEKGGH LGRDNVSDIS SIASTSPQRP KHRN