TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.78.1.1
Endosomal/Lysosomal K+ channel of 504 aas and 12 TMSs with two 6 TMS repeat units, KEL or TMEM175 (Cang et al. 2015).  A mutation in the encoding gene is associated with Parkinson's disease (Jing et al. 2015). It forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion (Lee et al. 2017). TMEM175 plays a direct and critical role in lysosomal and mitochondrial functions as well as Parkinson's Disease (PD) pathogenesis (Jinn et al. 2017). The 3-D structures of the open and closed channels are known (Oh et al. 2020). Coding variants in TMEM175 which increase the propensity for Parkinson's disease, are likely to be responsible for the association in the TMEM175/GAK/DGKQ locus, which could be mediated by affecting glucocerebrosidase activity (Krohn et al. 2020).

Accession Number:Q9BSA9
Protein Name:Transmembrane protein 175
Length:504
Molecular Weight:55615.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Structure:
6WC9   6WCA   6WCB   6WCC     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MSQPRTPEQA LDTPGDCPPG RRDEDAGEGI QCSQRMLSFS DALLSIIATV MILPVTHTEI 
61:	SPEQQFDRSV QRLLATRIAV YLMTFLIVTV AWAAHTRLFQ VVGKTDDTLA LLNLACMMTI 
121:	TFLPYTFSLM VTFPDVPLGI FLFCVCVIAI GVVQALIVGY AFHFPHLLSP QIQRSAHRAL 
181:	YRRHVLGIVL QGPALCFAAA IFSLFFVPLS YLLMVTVILL PYVSKVTGWC RDRLLGHREP 
241:	SAHPVEVFSF DLHEPLSKER VEAFSDGVYA IVATLLILDI CEDNVPDPKD VKERFSGSLV 
301:	AALSATGPRF LAYFGSFATV GLLWFAHHSL FLHVRKATRA MGLLNTLSLA FVGGLPLAYQ 
361:	QTSAFARQPR DELERVRVSC TIIFLASIFQ LAMWTTALLH QAETLQPSVW FGGREHVLMF 
421:	AKLALYPCAS LLAFASTCLL SRFSVGIFHL MQIAVPCAFL LLRLLVGLAL ATLRVLRGLA 
481:	RPEHPPPAPT GQDDPQSQLL PAPC