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1.A.98 The Human T-Lymphotropic Virus 1 P13 protein (HTLV1-P13) Family

Human T-cell leukemia virus type-1 (HTLV-1) encodes a mitochondrial protein named p13. p13 mediates an inward K+ current in isolated mitochondria that leads to mitochondrial swelling, depolarization, increased respiratory chain activity and reactive oxygen species (ROS) production. These effects trigger the opening of the permeability transition pore and are dependent on the presence of K+ and on the amphipathic α-helical domain of p13. In the context of cells, p13 acts as a sensitizer to selected apoptotic stimuli. It shares some structural and functional analogies with viroporins, a class of small integral membrane proteins that form pores and alter membrane permeability (Silic-Benussi et al. 2010). p13 is essential for the establishment and maintenance of HTLV-1 infection in vivo (Edwards et al. 2011).

References associated with 1.A.98 family:

Edwards, D., C. Fenizia, H. Gold, M.F. de Castro-Amarante, C. Buchmann, C.A. Pise-Masison, and G. Franchini. (2011). Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence. Viruses 3: 861-885. 21994758
Georgieva, E.R., P.P. Borbat, C. Fanouraki, and J.H. Freed. (2020). High-yield production in E. coli and characterization of full-length functional p13 protein from human T-cell leukemia virus type 1. Protein Expr Purif 105659. [Epub: Ahead of Print] 32360379
Hyser, J.M. and M.K. Estes. (2015). Pathophysiological Consequences of Calcium-Conducting Viroporins. Annu Rev Virol 2: 473-496. 26958925
Silic-Benussi, M., O. Marin, R. Biasiotto, D.M. D''Agostino, and V. Ciminale. (2010). Effects of human T-cell leukemia virus type 1 (HTLV-1) p13 on mitochondrial K+ permeability: A new member of the viroporin family? FEBS Lett. 584: 2070-2075. 20170654