1.B.38.1.1
Large non-selective MSP porin of 574 aas, with short lived large ion conduction (Mathers et al. 1996). Contains MOSP_N and MOSP_C domains which exists as periplasmic hydrophilic monomers and trimeric porins, respectively. MOSP_C, destined for the OM, follows the canonical BAM pathway, but
formation of a stable periplasmic conformer of MOSP_N involves an export-related,
folding pathway not present in E. coli (Puthenveetil et al. 2017).
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| Accession Number: | P74914 |
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| Protein Name: | Msp |
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| Length: | 574 |
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| Molecular Weight: | 62610.00 |
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| Species: | Treponema denticola [158] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ion |
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| Pfam: |
PF02722
PF02707
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[1] “Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp.” Fenno J.C. et.al. 9023187
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1: MKKILSILMI LVLVGGVAFA QVEPEVRGSA TLSWGIDFGA GSETDYTKGG ADNHAVATHG
61: FYNTNNFQVR LPFFKRQDFA GGSASKEADV YADVSFKATP VATGWTESGK AVSVKAILHF
121: YGAYMTVYGK PDFKANKALG WDPINADDGD QGKDWFNPAF TGWGTKIGYK KADLMGLDVG
181: LKLGSNGSWH QKASDGKDGK RREKDSKYAF GLDFAMEPVE KYLGVEATIN ATLGKFFNKT
241: PLENPGDYGY NAGNVPANIG GKEGKSGMVN FGLAFKSEPI EEMTVKLGFD GVTGLTYTDN
301: EGKIQETLGW DAGLSVGYKW VDAALYLCGT GTKYQGYNVA GNDHTKWKNY GANMAAHLGF
361: VSDEEAKKGT GFVDGLAFHV TINAYDLLAK RNSEDIPEAT RKANIGALST YDAALTAYLE
421: ANPNKTEADF QADPANAAVV NAFKVAKALF KTKYASIPLG LNLGVSYKYD LTDSMWIKPY
481: AEFYAETNHY KQHADTYAGD PDKMIDKLYL GMAYELGVKF QPIEKVQVKA SWEHGKLNKD
541: TYEGSFNGGE YMIKTPLNHK MHNGTFVLSL KLTY