1.B.38.1.5
Outer membrane bipartite trimeric porin of 598 aas with an N-terminal MOSPN domain (in the periplasm), and a C-terminal MOSPC domain (cell surface localized), TprC/TprD. The MOSPN domain confers envelope integrity by anchoring the C-terminal porin domain to periplasmic structural constituents (Anand et al. 2015). Selection pressures exerted within human populations drive T. pallidum subsp. pallidum TrpC diversity by mutation of loop regions and by recombination(Kumar et al. 2018).
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| Accession Number: | O88138 |
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| Protein Name: | Tpr protein C |
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| Length: | 598 |
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| Molecular Weight: | 64736.00 |
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| Species: | Treponema pallidum (strain Nichols) [243276] |
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| Number of TMSs: | 1 |
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| Substrate |
molecule |
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1: MGRQVMQAGV LAGMVCAASG YAGVLTPQVS GTAQLQWGIA FQKNPRTGPG KHTHGFRTTN
61: SLTISLPLVS KHTHTRRGEA RSGVWAQLQL KDLAVELASS KSSTALSFTK PTASFQATLH
121: CYGAYLTVGT SPSCVVNFAQ LWKPFVTRAY SEKDTRYAPG FSGSGAKLGY QAHNVGNSGV
181: DVDIGFLSFL SNGAWDSTDT THSKYGFGAD ATLSYGVDRQ RLLTLELAGN ATLDQNYVKG
241: TEDSKNENKT ALLWGVGGRL TLEPGAGFRF SFALDAGNQH QSNAHAQTQE RAILKAREVF
301: RRVEGKLVQN LPNIMMPPGI TEQTTLIEMV GLAALIAEGT LGSAIQTVLA AGALAALVSQ
361: LVPNIEQGVR DVFRSSDPRV VTAKLLAFLE RAPMNALNID ALLRMQWKWL SSGIYFATAG
421: TNIFGKRVFA TTRAHYFDFA GFLKLETKSG DPYTHLLTGL NAGVEARVYI PLTYIRYRNN
481: GGYELNGAVP PGTINMPILG KAWCSYRIPL GSHAWLAPHT SVLGTTNRFN IINPAGNLLN
541: ERALQYQVGL TFSPFEKVEL SAQWEQGVLA DAPYMGIAES IWSERHFGTL VCGMKVTW