1.C.39.6.1
Sporozoite protein with MAC/Perforin domain (Homologous to Erylysin B) of 810 aas. Interacts and breaches host cell membranes (Tavares et al. 2014). CDC/MACPF
proteins contain a characteristic four-stranded beta-sheet that is flanked by two alpha-helical
bundles, which unfold to form two transmembrane beta-hairpins. Apicomplexan parasites
express CDC/MACPFs termed perforin-like proteins (PLPs). Wade and Tweten 2015 present insights into the assembly and regulation of the Apicomplexan CDC (ApiMACPF) molecular pore-forming mechanisms, necessary for osmotically driven rupture of the parasitophorous
vacuole and host cell membrane, and cell traversal by these parasites.
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| Accession Number: | B3L016 |
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| Protein Name: | Sporozoite protein with MAC/Perforin domain |
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| Length: | 844 |
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| Molecular Weight: | 93826.00 |
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| Species: | Plasmodium knowlesi (strain H) [5851] |
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| Number of TMSs: | 2 |
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| Substrate |
molecule |
|---|
1: MKPGNINNLL AIWCIIFSIY EYGYVGSLRI GLRRNYSQSR NPDQYGESEV DFRTSGQLRD
61: LGKHANILYN NISYNTKNEA SFLNQKKQLD DDDDDDLGDL YIDDDDDAST ATGGGSATSD
121: DDDLELPDKD EEGDEDAKNQ QISQDDAESS GREEGLKKNV KLSKQEKLIE DKKEQTNNTF
181: KKYLFKDDDE EESKKKLSGK SKSRDSNSLD DDNDKDDSGD DDDSEGDKTR SNTRDAMKKD
241: LSVFPGMYFA GIGYDSLFGN PLGESDSLTD PGYRGQIILM NWEFSNKGVA NDLATLQPLN
301: GWIRKENACS RAESIKECSS ISDYTKNLTA EASVSGSYMG FGAFSASTGY KKFLQETSKR
361: TTKTYLIKSN CVKYTVGLPP YVHWEQTTAF KNAVDGLPPH FIGLEAESEC ASDVYEQKKT
421: SEECESVHAW ITFFKTYGTH IIMEAQLGGK ITKVVRVENT SVNQMKKDGI SVKAQVKAQF
481: GFASVGGSTN VSSDNSSKTN ENNYEMSEQL VVIGGNPIKD VTKEENLYEW SKTVSTNPMP
541: INIRLLPIST IFESDDLKSS YEKALIYYTR LYGFSPHDTM QKDEKDIVKI LTASTTVTNI
601: GAPPISAECP HNMVVLFGFV IRQNFWDHTN KLRSYEMEIC ESGMSTCTSK QGSTNKYDVS
661: YTYIECGAQA LPFIEQVVNV SGTTYNSLKC PNDYSVLFGF GMATSSGKHQ SALYTYFTPC
721: RPGMKSCSLN MNNQDDKSYI YLVCVDATIW TGLNSLSLIA KDDLHTPVNK YKQFNDGELI
781: VTCPSEGTIL TGFYGETHTS SPYVKAPFGK CAKSLKACSV HGCGQAIGMH NYRTLFVVAL
841: CKND