1.C.49 The Cytotoxic Amylin (Amylin) Family
The islet amyloid polypeptide (IAPP) precursor (amylin) of mammals is secreted and processed to form channel-forming peptides. These precursor proteins are homologous to calcitonin precursors. The human amylin forms channels in lipid bilayers that are permeable to Na
Islet amyloid polypeptide (IAPP) and insulin are copackaged and cosecreted by pancreatic islet
The transport reaction catalyzed by amylin is:
ions (in) ions (out).