TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.5.1.1









ε-toxin (epsilon toxin; ETx) type B precursor, EtxB, of 328 aas.  Forms heptameric pores (Miyata et al. 2002).  However, it has been reported to act on oligodendrocytes causing demyelination without forming pores (Wioland et al. 2015). The toxin acts on the brain, affecting vascular permeability, but also damaging neurons, astrocytes and oligodendrocytes (Freedman et al. 2016). The pore-forming regions are initially folded up on the surfaces of the soluble precursors. To create the transmembrane pores, these regions must extend and refold into membrane-inserted beta-barrels (Tilley and Saibil 2006). The crystal structure of epsilon-toxin revealed structural similarity to aerolysin from Aeromonas hydrophila.(Cole et al. 2004). Residues in the central position of each beta-strand of the amphipathic beta-hairpin loop that forms the transmembrane pore, control the size and ion selectivity of the channel (Knapp et al. 2020). The pre-pore morphology of ETX) has been provided (Ji et al. 2023). The ETX pore is formed in two stages: ETX monomers first attach to the membrane and form a pre-pore with no special conditions required, which then undergo a conformational change to form a transmembrane pore at temperatures above the critical point in the presence of receptors (Ji et al. 2023).

Bacteria
Bacillota
EtxB or ETX of Clostridium perfringens
1.C.5.1.2









Rhodanese-related sulfurtransferase of 319 aas and 1 N-terminal TMS.

Bacteria
Bacillota
Sulfur transferase of Paenibacillus popilliae
1.C.5.1.3









Poly-gamma-glutamate biosynthesis protein of 295 aas and 0 TMSs.

Bacteria
Bacillota
PGG biosynthesis protein of Clostridium botulinum
1.C.5.2.1









Mosquitocidal toxin, Mtx3
Bacteria
Bacillota
Mtx3 of Bacillus sphaericus (Q57028)
1.C.5.2.2









Mosquitocidal toxin, Mtx2
Bacteria
Bacillota
Mtx2 of Bacillus sphaericus (Q45470)
1.C.5.2.3









Uncharacterized protein of 319 aas, Sip1A

Bacteria
Bacillota
Sip1A of Lysinibacillus sphaericus
1.C.5.3.1









Parasporal crystal protein C53

Bacteria
Bacillota
C53 of Bacillus thurengiensis (Q45728)