TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.8.1.1









Botulinum neurotoxin types A-G.  Poly(amindo)amine (PAMAM) detrimers block activity (Förstner et al. 2014).  BoNTs inhibit synaptic exocytosis; intoxication requires the di-chain protein to undergo conformational changes in response to pH and redox gradients across the endosomal membrane with consequent formation of a protein-conducting channel by the heavy chain (HC) that translocates the light chain (LC) protease into the cytosol, colocalizing it with the substrate SNARE proteins (Montal 2009). Botulinum toxin type A inhibits salivary secretion, possibly by alterring RNA synthesis (Mao et al. 2020).

Bacteria
Firmicutes
Botulinum neurotoxin precursor, type A of Clostridium botulinum
1.C.8.1.2









Tetanus neurotoxin
Bacteria
Firmicutes
Tetanus neurotoxin precursor of Clostridium tetani
1.C.8.1.3









Clostridium botulinum neurotoxin type E (3d structure known (Kumaran et al., 2009))

Bacteria
Firmicutes
BoNTE of Clostridium botulinum (Q00496)
1.C.8.1.4









Non-toxic nonhemagglutinin type C of 1196 aas.  Assembles with botulinum neurotoxin type C (BoNT/C) and protects it against pH-mediated inactivation or protease activity at pH 2.6 (the pH of the animal gastrointestinal tract) but not at pH 6.0. The non-toxic component is necessary to maintain toxicity.

Viruses
Caudovirales
Nonhemagglutinin type C of Clostridium botulinum C phage (Clostridium botulinum C bacteriophage)