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1.D.12 The Beauvericin (Beauvericin) Family

Beauvericin is a cyclic hexadepsipeptide consisting of an alternating sequence of 3 D-α hydroxy-iso-valeryl and 3 N-methylphenylalanyl residues. It was originally isolated from Beauveria bassiana but has been detected in various fungal species including Fusarium spp. Beauvericin has antibiotic, insecticidal, apoptotic and cholesterol acyltransferase inhibiting activities.

Beauvericin is a cation-selective ionophore, transporting Na+, K+ and Ca2+. Activity has been demonstrated in liposomes and in myocytes and is blocked by La3+.

The reaction catalyzed by beauvericin is:

cation (in) cation (out)

References associated with 1.D.12 family:

Kouri, K., M. Lemmens, and R. Lemmens-Gruber. (2003). Beauvericin-induced channels in ventricular myocytes and liposomes. Biochim. Biophys. Acta 1609: 203-210. 12543382