1.D.315.  The Periodic Mesoporous Organosilica (PMO) Family 

Bioinspired nanochannel-based sensors have elicited interest because of their excellent sensing performance, as well as their robust mechanical and tunable chemical properties. A heteromembrane system composed of a periodic mesoporous organosilica (PMO) layer with three-dimensional (3D) network nanochannels has been constructed for glutathione (GSH) detection. The unique hierarchical pore architecture provides a large surface area, abundant reaction sites and plentiful interconnected pathways for rapid ionic transport, contributing to efficient and sensitive detection. Moreover, the thioether groups in nanochannels can be selectively cleaved by GSH to generate hydrophilic thiol groups. Benefiting from the increased hydrophilic surface, the proposed sensor achieves efficient GSH detection with a detection limit of 1.2 μM by monitoring the transmembrane ionic current, and it shows good recovery ranges in fetal bovine serum sample detection (Zeng et al. 2024).