1.D.59 The Anion Transporting Perenosin (Perenosin) Family
Perenosins represent a new class of anion transporters consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole. The indole containing members of the perenosin family function as effective transmembrane Cl-/NO3- antiporters and H+/Cl- cotransporters in a manner similar to the prodigiosenes (TC# 1.D.58). The compounds reduce the viability of several types of cancer cells (Van Rossom et al. 2016).