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1.D.96.  The Stacked Imidazole I-Quartet Superstructure Channel (I-Quartet) Family 

Water permeability through artificial water channels formed by stacked imidazole I-quartet superstructures increases when the channel water molecules are highly organized. Correlating water structure with molecular transport is essential for understanding the underlying mechanisms of (fast) water translocation and channel selectivity (Kocsis et al. 2018). Water molecules exhibit a dipolar oriented wire structure within chiral I-quartet water channels both in the solid state and embedded in supported lipid bilayer membranes (SLBs). X-ray single-crystal structures show that crystallographic water wires exhibit dipolar orientation. Quantitative measures of hydrogen bond strength, connectivity, and the stability of the dipolar alignment in a membrane environment uncovered the interplay between the dipolar aligned water structure and water transport through the self-assembled I-quartets (Kocsis et al. 2018).

References associated with 1.D.96 family:

Kocsis, I., M. Sorci, H. Vanselous, S. Murail, S.E. Sanders, E. Licsandru, Y.M. Legrand, A. van der Lee, M. Baaden, P.B. Petersen, G. Belfort, and M. Barboiu. (2018). Oriented chiral water wires in artificial transmembrane channels. Sci Adv 4: eaao5603. 29582016