TCDB is operated by the Saier Lab Bioinformatics Group

1.D.98.  The bis-Diol Anion Channel (BD-AC) Family 

bis-Diol (see Fig. 7 in Gale et al. 2017) self-assembles in lipid bilayers to create Cl- (and OH-) channels (Saha et al. 2016). Transport of Cl-, mediated by OH:Cl- H bonds, induces apoptosis in cell lines. Vicinal diols, tethered to a rigid 1,3-diethynylbenzene core are pivotal moieties for barrel-rosette ion channel formation. The activity of such channels is tuned by controlling the lipophilicity of designed monomers. Selective transport of chloride ions via an antiport mechanism and channel formation in the lipid bilayer membranes were confirmed for the most active derivative. A theoretical model of the supramolecular barrel-rosette, favored by a network of intermolecular hydrogen bonding, was proposed (Saha et al. 2016).


References associated with 1.D.98 family:

Gale, P.A., J.T. Davis, and R. Quesada. (2017). Anion transport and supramolecular medicinal chemistry. Chem Soc Rev 46: 2497-2519. 28379234
Saha, T., A. Gautam, A. Mukherjee, M. Lahiri, and P. Talukdar. (2016). Chloride Transport through Supramolecular Barrel-Rosette Ion Channels: Lipophilic Control and Apoptosis-Inducing Activity. J. Am. Chem. Soc. 138: 16443-16451. 27933857