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1.G.9.2.3
The Human T-cell leukemia virus 1, HTLV-1, of 488 aas and 2 or 3 TMSs, N- and C-terminal with a possible additional TMS at residue 320. The glycine-rich region of this transmembrane protein is involved in membrane fusion. It is a class I viral fusion protein (Wilson et al. 2005). The N-terminal fusion peptide initiates virus-cell membrane fusion. The fusion peptide is linked to the coiled-coil core through a conserved sequence that is rich in glycines. Wilson et al. 2005 investigated the functional role of the glycine-rich segment, Met-326 to Ser-337, of gp21. Alanine substitution for the hydrophobic residue Ile-334 caused a 90% reduction in cell-cell fusion activity without a detectable effect on the lipid-mixing and pore forming phases of fusion. Retroviral glycoprotein fusion thus appears to require flexibility within the glycine-rich segment and hydrophobic contacts mediated by this segment (Wilson et al. 2005).  

Accession Number:P23064
Protein Name:Envelope glycoprotein gp62
Length:488
Molecular Weight:53856.00
Species:Human T-cell leukemia virus 1 (strain Japan MT-2 subtype A) (HTLV-1) [11928]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Virion membrane1 / Peripheral membrane protein2
Substrate

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FASTA formatted sequence
1:	MGKFLATLIL FFQFCPLILG DYSPSCCTLT IGVSSYHSKP CNPAQPVCSW TLDLLALSAD 
61:	QALQPPCPNL VSYSSYHATY SLYLFPHWIK KPNRNGGGYY SASYSDPCSL KCPYLGCQSW 
121:	TCPYTGAVSS PYWKFQQDVN FTQEVSRLNI NLHFSKCGFP FSLLVDAPGY DPIWFLNTEP 
181:	SQLPPTAPPL LPHSNLDHIL EPSIPWKSKL LTLVQLTLQS TNYTCIVCID RASLSTWHVL 
241:	YSPNVSVPSS SSTPLLYPSL ALPAPHLTLP FNWTHCFDPQ IQAIVSSPCH NSLILPPFSL 
301:	SPVPTLGSRS RRAVPVAVWL VSALAMGAGV AGGITGSMSL ASGKSLLHEV DKDISQLTQA 
361:	IVKNHKNLLK IAQYAAQNRR GLDLLFWEQG GLCKALQEQC CFLNITNSHV SILQERPPLE 
421:	NRVLTGWGLN WDLGLSQWAR EALQTGITLV ALLLLVILAG PCILRQLRHL PSRVRYPHYS 
481:	LINPESSL