1.W.4. The Viral Portal Protein 4 (PPP4) Family
Members of this family from eukaryotic viruses form portals in the viral capsid through which viral DNA is translocated during DNA packaging. The protein assembles as a dodecamer at a single fivefold axis of the T=16 icosahedric capsid. It binds to the molecular motor that translocates the viral DNA, termed terminase (Newcomb et al. 2001).
References associated with 1.W.4 family:
Dünn-Kittenplon, D., A. Ashkenazy-Titelman, I. Kalt, J.P. Lellouche, Y. Shav-Tal, and R. Sarid. (2021). The Portal Vertex of KSHV Promotes Docking of Capsids at the Nuclear Pores. Viruses 13:. 33807444
Newcomb, W.W., R.M. Juhas, D.R. Thomsen, F.L. Homa, A.D. Burch, S.K. Weller, and J.C. Brown. (2001). The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid. J. Virol. 75: 10923-10932. 11602732