TCDB is operated by the Saier Lab Bioinformatics Group

1.B.93.  The MipA-interacting Protein (MipA) Family 

The MipA family is a large family of outer membrane proteins called OmpV. MltA is designated as a lytic transglycosylase, and MipA may be a scaffolding protein in E. coli (Vollmer et al., 1999). Synthesis of the E. coli MipA is suppressed by glucose (Yang et al., 2011). It is related to the DUF2141 family. One member, YiaT of E. coli, has been considered to be a porin (Vinson et al., 2010). It may have ~10 TM β-strands, and may be a member of the large OMPP Superfamily 1. Evidence for this is as follows:  TC Blast searches with various members of the MipA family bring up members of the OMPP superfamily with low scores, but usually not proteins outside of this superfamily with similar scores.  Also, one of the proteins (TC# 1.B.93.1.3) hits 1.B.39.1.9 (a known member of the OMPP superfamily (Reddy and Saier 2016) with a score of e-6 (with filters, e-5) for centrally located 120 aa length segments in corresponding portions of the two proteins (residues 78 and 39 to residues 245 and 216, respectively).  These observations strengthen the possibility that MipA family proteins are porins of the OMPP superfamily.

References associated with 1.b.93 family:

Li, H., D.F. Zhang, X.M. Lin, and X.X. Peng. (2015). Outer membrane proteomics of kanamycin-resistant Escherichia coli identified MipA as a novel antibiotic resistance-related protein. FEMS Microbiol. Lett. 362:. 25940639
Reddy, B.L. and M.H. Saier, Jr. (2016). Properties and Phylogeny of 76 Families of Bacterial and Eukaryotic Organellar Outer Membrane Pore-Forming Proteins. PLoS One 11: e0152733. 27064789
van Straaten, K.E., B.W. Dijkstra, W. Vollmer, and A.M. Thunnissen. (2005). Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold. J. Mol. Biol. 352: 1068-1080. 16139297
Vinson, H.M., A. Gautam, S. Olet, P.S. Gibbs, and R. Barigye. (2010). Molecular analysis of porin gene transcription in heterogenotypic multidrug-resistant Escherichia coli isolates from scouring calves. J Antimicrob Chemother 65: 1926-1935. 20639525
Vollmer, W., M. von Rechenberg, and J.V. Höltje. (1999). Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli. J. Biol. Chem. 274: 6726-6734. 10037771
Yang, J.N., C. Wang, C. Guo, X.X. Peng, and H. Li. (2011). Outer membrane proteome and its regulation networks in response to glucose concentration changes in Escherichia coli. Mol Biosyst 7: 3087-3093. 21850335