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2.A.18.1.1
Auxin:H+ symporter (auxin influx), AUX, AUX1, AUX-1, or LAX (Reinhardt et al., 2003; Carraro et al., 2012).  In the PILS (Pin-like) family; members are located in the endoplasmic reticular membrane (Balzan et al. 2014).  Expression patterns of PILS family members have been studied (Mohanta et al. 2015). Involved in determination of first pod height (FPH), a quantitative trait in soybean [Glycine max (L.) Merr.] that affects mechanized harvesting (Jiang et al. 2018). Auxin regulates several aspects of plant growth and development and is predominantly synthesized in the shoot apex and developing leaf primordia and from there it is transported to the target tissues e.g. roots. It is essential for root development, root gravitropism, root hair development, vascular patterning, seed germination, apical hook formation, leaf morphogenesis, phyllotactic patterning, female gametophyte development embryo development and the regulation of plant responses to abiotic stresses (Swarup and Bhosale 2019).

Accession Number:Q96247
Protein Name:Aux-1 aka AUX1 aka F16M14.5 aka AT2G38120
Length:485
Molecular Weight:54060.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate hydron, auxin

Cross database links:

RefSeq: NP_565882.1   
Entrez Gene ID: 818390   
Pfam: PF01490   
KEGG: ath:AT2G38120   

Gene Ontology

GO:0009986 C:cell surface
GO:0005768 C:endosome
GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0010011 F:auxin binding
GO:0010328 F:auxin influx transmembrane transporter acti...
GO:0015293 F:symporter activity
GO:0006865 P:amino acid transport
GO:0009734 P:auxin mediated signaling pathway
GO:0009926 P:auxin polar transport
GO:0001736 P:establishment of planar polarity
GO:0010311 P:lateral root formation
GO:0009958 P:positive gravitropism
GO:0009624 P:response to nematode
GO:0048829 P:root cap development
GO:0048765 P:root hair cell differentiation

References (20)

[1] “Arabidopsis AUX1 gene: a permease-like regulator of root gravitropism.”  Bennett M.J.et.al.   8688077
[2] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “The aux1 mutation of Arabidopsis confers both auxin and ethylene resistance.”  Pickett F.B.et.al.   16667854
[5] “Ammonium inhibition of Arabidopsis root growth can be reversed by potassium and by auxin resistance mutations aux1, axr1, and axr2.”  Cao Y.et.al.   8278539
[6] “The AXR1 and AUX1 genes of Arabidopsis function in separate auxin-response pathways.”  Timpte C.et.al.   11536712
[7] “Genetic analysis of ethylene signal transduction in Arabidopsis thaliana: five novel mutant loci integrated into a stress response pathway.”  Roman G.et.al.   7768447
[8] “Genetic analysis of the effects of polar auxin transport inhibitors on root growth in Arabidopsis thaliana.”  Fujita H.et.al.   9032965
[9] “Differential effects of 1-naphthaleneacetic acid, indole-3-acetic acid and 2,4-dichlorophenoxyacetic acid on the gravitropic response of roots in an auxin-resistant mutant of Arabidopsis, aux1.”  Yamamoto M.et.al.   9697346
[10] “Auxin and ethylene promote root hair elongation in Arabidopsis.”  Pitts R.J.et.al.   10036773
[11] “The Arabidopsis AUX1 gene: a model system to study mRNA processing in plants.”  Marchant A.et.al.   9484486
[12] “AUX1 regulates root gravitropism in Arabidopsis by facilitating auxin uptake within root apical tissues.”  Marchant A.et.al.   10205161
[13] “Auxin is a positive regulator for ethylene-mediated response in the growth of Arabidopsis roots.”  Rahman A.et.al.   11266581
[14] “Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex.”  Swarup R.et.al.   11641271
[15] “Novel auxin transport inhibitors phenocopy the auxin influx carrier mutation aux1.”  Parry G.et.al.   11260496
[16] “Chromosaponin I specifically interacts with AUX1 protein in regulating the gravitropic response of Arabidopsis roots.”  Rahman A.et.al.   11161055
[17] “Cell polarity signaling in Arabidopsis involves a BFA-sensitive auxin influx pathway.”  Grebe M.et.al.   11864575
[18] “Auxin and ethylene response interactions during Arabidopsis root hair development dissected by auxin influx modulators.”  Rahman A.et.al.   12481073
[19] “AUX1 promotes lateral root formation by facilitating indole-3-acetic acid distribution between sink and source tissues in the Arabidopsis seedling.”  Marchant A.et.al.   11910006
[20] “Structure-function analysis of the presumptive Arabidopsis auxin permease AUX1.”  Swarup R.et.al.   15486104

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Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MSEGVEAIVA NDNGTDQVNG NRTGKDNEEH DGSTGSNLSN FLWHGGSVWD AWFSCASNQV 
61:	AQVLLTLPYS FSQLGMLSGI VLQIFYGLLG SWTAYLISVL YVEYRARKEK EGKSFKNHVI 
121:	QWFEVLDGLL GSYWKALGLA FNCTFLLFGS VIQLIACASN IYYINDHLDK RTWTYIFGAC 
181:	CATTVFIPSF HNYRIWSFLG LGMTTYTAWY LAIASIIHGQ AEGVKHSGPT KLVLYFTGAT 
241:	NILYTFGGHA VTVEIMHAMW KPQKFKYIYL MATLYVFTLT IPSAAAVYWA FGDALLDHSN 
301:	AFSLMPKNAW RDAAVILMLI HQFITFGFAC TPLYFVWEKV IGMHDTKSIC LRALARLPVV 
361:	IPIWFLAIIF PFFGPINSAV GALLVSFTVY IIPSLAHMLT YRSASARQNA AEKPPFFMPS 
421:	WTAMYVLNAF VVVWVLIVGF GFGGWASVTN FVRQVDTFGL FAKCYQCKPA AAAAHAPVSA 
481:	LHHRL