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2.A.18.2.2
Lysine/histidine transporter, LHT1, of 446 aas and 10 or 11 TMSs (Chen and Bush 1997).  It has been reported to be an amino acid-proton symporter with a broad specificity for histidine, lysine, glutamic acid, alanine, serine, proline and glycine 90. It is involved in both apoplastic transport of amino acids in leaves and their uptake by roots (Hirner et al. 2006; Svennerstam et al. 2007; Svennerstam et al. 2008). There is some controversy about which amino acids it can take up, but it may play a role in fungicide uptake (Wu et al. 2021).

Accession Number:Q9FKS8
Protein Name:Lysine histidine transporter 1
Length:446
Molecular Weight:49814.00
Species: [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate lysine, Histidine

Cross database links:

RefSeq: NP_198894.2    NP_851109.1   
Entrez Gene ID: 834078   
Pfam: PF01490   
KEGG: ath:AT5G40780   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0043090 P:amino acid import

References (8)

[1] “LHT1, a lysine- and histidine-specific amino acid transporter in arabidopsis.”  Chen L.et.al.   9390441
[2] “Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.”  Kaneko T.et.al.   9679202
[3] “Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence features of the regions of 1,013,767 bp covered by sixteen physically assigned P1 and TAC clones.”  Nakamura Y.et.al.   9872454
[4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[5] “Selective expression of a novel high-affinity transport system for acidic and neutral amino acids in the tapetum cells of Arabidopsis flowers.”  Lee Y.-H.et.al.   15361141
[6] “Arabidopsis LHT1 is a high-affinity transporter for cellular amino acid uptake in both root epidermis and leaf mesophyll.”  Hirner A.et.al.   16816136
[7] “Comprehensive screening of Arabidopsis mutants suggests the lysine histidine transporter 1 to be involved in plant uptake of amino acids.”  Svennerstam H.et.al.   17293438
[8] “Root uptake of cationic amino acids by Arabidopsis depends on functional expression of amino acid permease 5.”  Svennerstam H.et.al.   18681934

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVAQAPHDDH QDDEKLAAAR QKEIEDWLPI TSSRNAKWWY SAFHNVTAMV GAGVLGLPYA 
61:	MSQLGWGPGI AVLVLSWVIT LYTLWQMVEM HEMVPGKRFD RYHELGQHAF GEKLGLYIVV 
121:	PQQLIVEIGV CIVYMVTGGK SLKKFHELVC DDCKPIKLTY FIMIFASVHF VLSHLPNFNS 
181:	ISGVSLAAAV MSLSYSTIAW ASSASKGVQE DVQYGYKAKT TAGTVFNFFS GLGDVAFAYA 
241:	GHNVVLEIQA TIPSTPEKPS KGPMWRGVIV AYIVVALCYF PVALVGYYIF GNGVEDNILM 
301:	SLKKPAWLIA TANIFVVIHV IGSYQIYAMP VFDMMETLLV KKLNFRPTTT LRFFVRNFYV 
361:	AATMFVGMTF PFFGGLLAFF GGFAFAPTTY FLPCVIWLAI YKPKKYSLSW WANWVCIVFG 
421:	LFLMVLSPIG GLRTIVIQAK GYKFYS