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2.A.18.2.5
General amino acid transporter 8, AAP8 (transports all amino acids, but the basic amino acids are transported
with low affinity (Okumoto et al., 2002)). It is a proton symporter with broad specificity for acidic and neutral amino acids, and is important for seed development (Schmidt et al. 2007) as well as phloem loading with amino acids (Santiago and Tegeder 2016). It contributes (as does AAP1) to grain quality (Yang et al. 2021).

Accession Number:O80592
Protein Name:AAP8
Length:475
Molecular Weight:51815.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

RefSeq: NP_172472.1   
Entrez Gene ID: 837536   
Pfam: PF01490   
KEGG: ath:AT1G10010   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006865 P:amino acid transport

References (3)

[1] “High affinity amino acid transporters specifically expressed in xylem parenchyma and developing seeds of Arabidopsis.”  Okumoto S.et.al.   12244056
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “The amino acid permease AAP8 is important for early seed development in Arabidopsis thaliana.”  Schmidt R.et.al.   17476526

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDAYNNPSAV ESGDAAVKSV DDDGREKRTG TFWTASAHII TAVIGSGVLS LAWAIAQLGW 
61:	VAGTTVLVAF AIITYYTSTL LADCYRSPDS ITGTRNYNYM GVVRSYLGGK KVQLCGVAQY 
121:	VNLVGVTIGY TITASISLVA IGKSNCYHDK GHKAKCSVSN YPYMAAFGIV QIILSQLPNF 
181:	HKLSFLSIIA AVMSFSYASI GIGLAIATVA SGKIGKTELT GTVIGVDVTA SEKVWKLFQA 
241:	IGDIAFSYAF TTILIEIQDT LRSSPPENKV MKRASLVGVS TTTVFYILCG CIGYAAFGNQ 
301:	APGDFLTDFG FYEPYWLIDF ANACIALHLI GAYQVYAQPF FQFVEENCNK KWPQSNFINK 
361:	EYSSKVPLLG KCRVNLFRLV WRTCYVVLTT FVAMIFPFFN AILGLLGAFA FWPLTVYFPV 
421:	AMHIAQAKVK KYSRRWLALN LLVLVCLIVS ALAAVGSIIG LINSVKSYKP FKNLD