2.A.18.5.5
The aggression-related transporter, CG13646 of 527 aas and 11 TMSs. Reduction in expression of CG13646 by
approximately half leads to a hyperaggressive phenotype partially resembling that seen in Bully
flies (Chowdhury et al. 2017). Members of this family are involved in glutamine/glutamate and GABA cycles of metabolism in
excitatory and inhibitory nerve terminals. D. melanogaster provides a model for unraveling unique molecular features of epilepsy elicited by human GABA transporter 1 variants (Kasture et al. 2022).
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| Accession Number: | Q9VC02 |
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| Protein Name: | Uncharacterized protein |
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| Length: | 527 |
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| Molecular Weight: | 58960.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 11 |
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| Substrate |
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1: MFFFRRQNAK PAPRPSRAPS FALPKRRPPV QLTPSHQHDQ LPFLRRSRFS ALPHFRAYED
61: EPENLSLFIA ILYVVDLFGI FPFVTLPALL VKLGYFGILL VLSIIILQIY TSFLLSQCWT
121: MAELLDPSIQ QKRNYPYAAL AELAYGPYMS LLVSVLLDLS IFAMAVPSVV MAAQNLEGVV
181: LRMSAGQYNF SYCYWAIIVG LVICPLMWLG SPKHMRGLAI IAVCVMIVIV ALLWFCLFAA
241: PAIGTPFEGI SLELPGFLTV LNSYSILAFQ FDIHPVLLTL QIDMKQKSQV SWAALIGIAI
301: TCSVAIFGSI IAAYKFGSMI ADNLLQSLPT SVPFYVMLIL MALQLCFSVT VASSAMFMQI
361: ENYFKLPESL SFKRMLIRSS VLALEVLVAE FVPSFDALMD VVGGTITGPL VFILPPLLYR
421: RIRRMERVHQ RIAAEASYGS LPLDLNYDPV DLEMEPLLVI SPPTTPRGCW LRFVRLLHRL
481: ECDVSCTMAV LIFGLLATFL STYLNIFSLA SLFTNNSPCL SNLTKHF