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2.A.18.6.11
SLC38 member 6, SNAT6. Na+-dependent synaptic vesicle amino acid release porter (Gasnier, 2004) (transports amino acids,glutamate,  glutamine, glycine and γ-amino butyric acid (GABA)).  It seems to be the only glutamine transporter in the brain, being present in excitatory neurons, particularly at the synapses (Bagchi et al. 2014). Glutamine uptake via SNAT6 and caveolin (TC# 8.A.26) regulates the glutamine-glutamate cycle (Gandasi et al. 2021). It exhibits a high degree of specificity for glutamine and glutamate, and the presence of these substrates enables formation of SNAT6-caveolin complexes that aid in sodium-dependent trafficking. Interacting partners of SNAT6 include CTP synthase 2 (CTPs2), phosphate-activated glutaminase (Pag; Kvamme et al. 2001), and glutamate metabotropic receptor 2 (Grm2; TC# 9.A.14.7.9) (Gandasi et al. 2021).

Accession Number:Q8IZM9
Protein Name:Probable sodium-coupled neutral amino acid transporter 6
Length:456
Molecular Weight:50929.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Entrez Gene ID: 145389   
Pfam: PF01490   
KEGG: hsa:145389    hsa:145389    hsa:145389   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0006865 P:amino acid transport
GO:0006814 P:sodium ion transport

References (9)

[1] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family.”  Mackenzie B.et.al.   12845534
[4] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family.”  Mackenzie B.et.al.   12845534
[7] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family.”  Mackenzie B.et.al.   12845534

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEASWGSFNA ERGWYVSVQQ PEEAEAEELS PLLSNELHRQ RSPGVSFGLS VFNLMNAIMG 
61:	SGILGLAYVL ANTGVFGFSF LLLTVALLAS YSVHLLLSMC IQTAVTSYED LGLFAFGLPG 
121:	KLVVAGTIII QNIGAMSSYL LIIKTELPAA IAEFLTGDYS RYWYLDGQTL LIIICVGIVF 
181:	PLALLPKIGF LGYTSSLSFF FMMFFALVVI IKKWSIPCPL TLNYVEKGFQ ISNVTDDCKP 
241:	KLFHFSKESA YALPTMAFSF LCHTSILPIY CELQSPSKKR MQNVTNTAIA LSFLIYFISA 
301:	LFGYLTFYDK VESELLKGYS KYLSHDVVVM TVKLCILFAV LLTVPLIHFP ARKAVTMMFF 
361:	SNFPFSWIRH FLITLALNII IVLLAIYVPD IRNVFGVVGA STSTCLIFIF PGLFYLKLSR 
421:	EDFLSWKKLG AFVLLIFGIL VGNFSLALII FDWINK