2.A.18.7.5
Amino acid transporter-6, AAT6 of 488 aas and 11 TMSs. Transports neutral amino acids and the drug, eflornithine (Schmidt et al. 2018). Eflornithine is used in combination with nifurtimox to combat T. brucei disease, and resistance to eflornithine is caused by the deletion or mutation of TbAAT6 which transports eflornithine into the cell (Kasozi et al. 2022).
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| Accession Number: | Q57UL7 |
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| Protein Name: | Amino acid transporter, putative |
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| Length: | 488 |
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| Molecular Weight: | 52891.00 |
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| Species: | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) [185431] |
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| Number of TMSs: | 11 |
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| Substrate |
amino acid, drug |
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1: MREPIQTSTP VSTGETDPAV VAAEHANPSV FSVPVVAHDV APDAVTASTA VTDVNVEVQS
61: GGTKDITVSS SPRKEAGVIP ENTNIYKTAF HIFKANVGTA VFLLPVFYQD AGYILGPTIA
121: VLIGVCVIDA SQLLLGTKLT IDRPRVDTYG RICKFIFGPP LQWVLFVCLL LSQFGFCLLY
181: MQLTVDTMNT MVQFKGDTYV WSFVMFFIEF GFTCFSSNFS TLAIISISAS VAVTFTLVAT
241: FVGTCMEINK NGRVHPTVNA FGNNIPIGWF NNMASNLMGL EGIAIVLPAH TGCNQKTRFK
301: FTLSLVLTLT VSIYLLYGIT GYLAYGTSIN TSIIDGLPES QLSTAVRAML VINLVCTYPV
361: QFQSAIQAVD QVVGCSAFSV KGILLRLFIN LVIVSIELAV GPKAVHAVVS LIGALPAAVM
421: VFILPALLTM QVDHAVMNPE EDRVTLKYWG SMFTAAPVFS WTRIRCYFYI IFGLIVMVMG
481: TYSVIAEL