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| Accession Number: | P55016 |
| Protein Name: | NKC2 aka SLC12A1 aka NKCC2 |
| Length: | 1095 |
| Molecular Weight: | 120597.00 |
| Species: | Rattus norvegicus (Rat) [10116] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | sodium chloride, potassium chloride |
Cross database links:
| Pfam: | PF00324 PF08403 |
|---|---|
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0008511
F:sodium:potassium:chloride symporter activity
GO:0006821
P:chloride transport
GO:0006813
P:potassium ion transport
GO:0006814
P:sodium ion transport
GO:0055085
P:transmembrane transport
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References (1)[1] “Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.” Gamba G.et.al. 8021284
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSVNIPSNSV PSGASRFQVH VINEGHGSGA AMSDSTDPPH YEETSFGDEA QNRLKISFRP 61: GNQECYENFL QTGETAKTDT TFHAYDSHTN TYYLQTFGHN TMDAVPKIEY YRNTGSVSGP 121: KVNRPSLQEI HEQLAKNVAV APGSADRVAN GDGMPGDEQA ENKEEDVTGV VKFGWVKGVL 181: VRCMLNIWGV MLFIRLSWIV GEAGIGLGVI IIGLSVVVTT LTGISMSAIC TNGVVRGGGA 241: YYLISRSLGP EFGGSIGLIF RFANAVRVAM YVVGFAETVV DLLKESDSMM VDPTNDIRII 301: GSITVVILLG ISVAGMEWEA KAQVILLVIL LIGIANFFIG TVIPSNNEKK SRGFFNYQAS 361: IFAENFGPSF TEGEGFFSVF AIFFPAATGI LAGANISGDL EDPQDAIPRG TMLAIFITTV 421: AYIGVAICVR ACVVRDATGS MNDTVVSGMN CNGSAACGLG YDFSRCQHEP CQYGLMNNFQ 481: VMSMVSGFGP LITAGIFSAT LSSALASLVS APKVFQALCK DNIFKGLQFF AKGYGKNNEP 541: LRGYFLTFVI AMAFILIAEL NVIAPIISNF FLASYALINF SCFHASYAKS PGWRPAYGIY 601: NMWVSLFGAI LCCAVMFVIN WWAAVITYVI ELFLYIYVTY KKPDVNWGSS TQALSYVSAL 661: DNALELTTVE DHVKNFRPQC IVLTGGPMTR PALLDITHAF TKNSGLCICC EVFVGPRKLC 721: VKEMNSGMAK KQAWLMKNKI KAFYAAVAAD CFRDGVRSLL QASGLGRMKP NTLVIGYKKN 781: WRKAPLSELE NYVGIIHDAF DFEIGVVIVR ISQGFDISPV LQVQDELEKL EQERLALEAA 841: IKDNDCEEGK GGIRGLFKKA GKLNITKPAP KKDSNISTIQ SMHVGEFNQK LVEASAQFKK 901: KQGKGTIDVW WLFDDGGLTL LIPYILTLRK KWKDCKLRIY VGGKINRIEE EKISMASLLS 961: KFRIKFADIH IIGDINIKPN KESWKVFEEM IEPYRLHESH KDLTTAEKLK RESPWKITDA 1021: ELEAVKEKSY RQVRLNELLQ EHSRAANLIV LSLPVARKGS ISDLLYMAWL EILTKNLPPV 1081: LLVRGNHKNV LTFYS