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2.A.30.1.1 NaCl/KCl symporter; the orthologue in humans when mutated can be responsible for Bartter syndrome, an autosomal recessive disease (Stechman et al., 2007).
Accession Number:	P55016
Protein Name:	NKC2 aka SLC12A1 aka NKCC2
Length:	1095
Molecular Weight:	120597.00
Species:	Rattus norvegicus (Rat) [10116]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	NaCl, KCl

Pfam:	PF00324 PF08403
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0008511 F:sodium:potassium:chloride symporter activity GO:0006821 P:chloride transport GO:0006813 P:potassium ion transport GO:0006814 P:sodium ion transport GO:0055085 P:transmembrane transport
References (1) [1] “Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.” Gamba G.et.al. 8021284

BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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FASTA formatted sequence

1:	MSVNIPSNSV PSGASRFQVH VINEGHGSGA AMSDSTDPPH YEETSFGDEA QNRLKISFRP 
61:	GNQECYENFL QTGETAKTDT TFHAYDSHTN TYYLQTFGHN TMDAVPKIEY YRNTGSVSGP 
121:	KVNRPSLQEI HEQLAKNVAV APGSADRVAN GDGMPGDEQA ENKEEDVTGV VKFGWVKGVL 
181:	VRCMLNIWGV MLFIRLSWIV GEAGIGLGVI IIGLSVVVTT LTGISMSAIC TNGVVRGGGA 
241:	YYLISRSLGP EFGGSIGLIF RFANAVRVAM YVVGFAETVV DLLKESDSMM VDPTNDIRII 
301:	GSITVVILLG ISVAGMEWEA KAQVILLVIL LIGIANFFIG TVIPSNNEKK SRGFFNYQAS 
361:	IFAENFGPSF TEGEGFFSVF AIFFPAATGI LAGANISGDL EDPQDAIPRG TMLAIFITTV 
421:	AYIGVAICVR ACVVRDATGS MNDTVVSGMN CNGSAACGLG YDFSRCQHEP CQYGLMNNFQ 
481:	VMSMVSGFGP LITAGIFSAT LSSALASLVS APKVFQALCK DNIFKGLQFF AKGYGKNNEP 
541:	LRGYFLTFVI AMAFILIAEL NVIAPIISNF FLASYALINF SCFHASYAKS PGWRPAYGIY 
601:	NMWVSLFGAI LCCAVMFVIN WWAAVITYVI ELFLYIYVTY KKPDVNWGSS TQALSYVSAL 
661:	DNALELTTVE DHVKNFRPQC IVLTGGPMTR PALLDITHAF TKNSGLCICC EVFVGPRKLC 
721:	VKEMNSGMAK KQAWLMKNKI KAFYAAVAAD CFRDGVRSLL QASGLGRMKP NTLVIGYKKN 
781:	WRKAPLSELE NYVGIIHDAF DFEIGVVIVR ISQGFDISPV LQVQDELEKL EQERLALEAA 
841:	IKDNDCEEGK GGIRGLFKKA GKLNITKPAP KKDSNISTIQ SMHVGEFNQK LVEASAQFKK 
901:	KQGKGTIDVW WLFDDGGLTL LIPYILTLRK KWKDCKLRIY VGGKINRIEE EKISMASLLS 
961:	KFRIKFADIH IIGDINIKPN KESWKVFEEM IEPYRLHESH KDLTTAEKLK RESPWKITDA 
1021:	ELEAVKEKSY RQVRLNELLQ EHSRAANLIV LSLPVARKGS ISDLLYMAWL EILTKNLPPV 
1081:	LLVRGNHKNV LTFYS

2.A.30.1.1
NaCl/KCl symporter; the orthologue in humans when mutated can be responsible for Bartter syndrome, an autosomal recessive disease (Stechman et al., 2007).

Cross database links:

Gene Ontology

References (1)

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2.A.30.1.1NaCl/KCl symporter; the orthologue in humans when mutated can be responsible for Bartter syndrome, an autosomal recessive disease (Stechman et al., 2007).

Cross database links:

Gene Ontology

References (1)

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Analyze:

2.A.30.1.1
NaCl/KCl symporter; the orthologue in humans when mutated can be responsible for Bartter syndrome, an autosomal recessive disease (Stechman et al., 2007).