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Accession Number: | P55011 |
Protein Name: | NKC1 aka SLC12A2 aka NKCC1 |
Length: | 1212 |
Molecular Weight: | 131447.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 11 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate |
Cross database links:
RefSeq: | NP_001037.1 |
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Entrez Gene ID: | 6558 |
Pfam: | PF00324 PF08403 |
OMIM: |
600840 gene |
KEGG: | hsa:6558 hsa:6558 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0051739
F:ammonia transmembrane transporter activity
GO:0008511
F:sodium:potassium:chloride symporter activity
GO:0006813
P:potassium ion transport
GO:0006814
P:sodium ion transport
GO:0070634
P:transepithelial ammonium transport
GO:0030321
P:transepithelial chloride transport
GO:0055085
P:transmembrane transport
GO:0016324
C:apical plasma membrane
GO:0016323
C:basolateral plasma membrane
GO:0060444
P:branching involved in mammary gland duct morphogenesis
GO:0050910
P:detection of mechanical stimulus involved in sensory perception of sound
GO:0060763
P:mammary duct terminal end bud growth
GO:0035264
P:multicellular organism growth
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References (11)[1] “Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon.” Payne J.A.et.al. 7629105 [2] “Quantitation of Na(+)-K(+)-2Cl(-) cotransport splice variants in human tissues using kinetic polymerase chain reaction.” Vibat C.R.et.al. 11700976 [3] “ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.” Matsuoka S.et.al. 17525332 [4] “Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.” Cantin G.T.et.al. 18220336 [5] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [6] “Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon.” Payne J.A.et.al. 7629105 [7] “Quantitation of Na(+)-K(+)-2Cl(-) cotransport splice variants in human tissues using kinetic polymerase chain reaction.” Vibat C.R.et.al. 11700976 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MEPRPTAPSS GAPGLAGVGE TPSAAALAAA RVELPGTAVP SVPEDAAPAS RDGGGVRDEG 61: PAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA AAAAAAAGAG AGAKQTPADG 121: EASGESEPAK GSEEAKGRFR VNFVDPAASS SAEDSLSDAA GVGVDGPNVS FQNGGDTVLS 181: EGSSLHSGGG GGSGHHQHYY YDTHTNTYYL RTFGHNTMDA VPRIDHYRHT AAQLGEKLLR 241: PSLAELHDEL EKEPFEDGFA NGEESTPTRD AVVTYTAESK GVVKFGWIKG VLVRCMLNIW 301: GVMLFIRLSW IVGQAGIGLS VLVIMMATVV TTITGLSTSA IATNGFVRGG GAYYLISRSL 361: GPEFGGAIGL IFAFANAVAV AMYVVGFAET VVELLKEHSI LMIDEINDIR IIGAITVVIL 421: LGISVAGMEW EAKAQIVLLV ILLLAIGDFV IGTFIPLESK KPKGFFGYKS EIFNENFGPD 481: FREEETFFSV FAIFFPAATG ILAGANISGD LADPQSAIPK GTLLAILITT LVYVGIAVSV 541: GSCVVRDATG NVNDTIVTEL TNCTSAACKL NFDFSSCESS PCSYGLMNNF QVMSMVSGFT 601: PLISAGIFSA TLSSALASLV SAPKIFQALC KDNIYPAFQM FAKGYGKNNE PLRGYILTFL 661: IALGFILIAE LNVIAPIISN FFLASYALIN FSVFHASLAK SPGWRPAFKY YNMWISLLGA 721: ILCCIVMFVI NWWAALLTYV IVLGLYIYVT YKKPDVNWGS STQALTYLNA LQHSIRLSGV 781: EDHVKNFRPQ CLVMTGAPNS RPALLHLVHD FTKNVGLMIC GHVHMGPRRQ AMKEMSIDQA 841: KYQRWLIKNK MKAFYAPVHA DDLREGAQYL MQAAGLGRMK PNTLVLGFKK DWLQADMRDV 901: DMYINLFHDA FDIQYGVVVI RLKEGLDISH LQGQEELLSS QEKSPGTKDV VVSVEYSKKS 961: DLDTSKPLSE KPITHKVEEE DGKTATQPLL KKESKGPIVP LNVADQKLLE ASTQFQKKQG 1021: KNTIDVWWLF DDGGLTLLIP YLLTTKKKWK DCKIRVFIGG KINRIDHDRR AMATLLSKFR 1081: IDFSDIMVLG DINTKPKKEN IIAFEEIIEP YRLHEDDKEQ DIADKMKEDE PWRITDNELE 1141: LYKTKTYRQI RLNELLKEHS STANIIVMSL PVARKGAVSS ALYMAWLEAL SKDLPPILLV 1201: RGNHQSVLTF YS