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2.A.31.1.4
Anion exchanger 1 (AE1, Band 3 anion exchanger, Slc4a1) of 918 aas and 13 TMSs in a 1 + 12 TMS arrangement that looks like a 1 + 6 + 6 arrangement.  The protein functions both as a transporter that mediates electroneutral inorganic anion exchange (e.g., Cl- against HCO3-) across the cell membrane and as a structural protein. It is a major integral membrane glycoprotein of the erythrocyte membrane required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its N-terminal cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. It mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. A mutant containing the sole C462 can drive a marginal Cl- current, but the minimal configuration necessary to get optimal functional expression includes residues C462, C583 and C588 (Martial et al. 2007). Trout AE1 can function both as a antiporter or a channel, and mutations affecting one or the other function or both have been isolated (Martial et al. 2006).

Accession Number:P32847
Protein Name:Band 3 anion exchange protein
Length:918
Molecular Weight:101894.00
Species:Oncorhynchus mykiss (Rainbow trout) [8022]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cl-, bicarbonate, anions

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FASTA formatted sequence
1:	MENDLSFGED VMSYEEESDS AFPSPIRPTP PGHSGNYDLE QSRQEEDSNQ AIQSIVVHTD 
61:	PEAYLNLNTN ANTRGDAQAY VELNELMGNS WQETGRWVGY EENFNPGTGK WGPSHVSYLT 
121:	FKSLIQLRKI MSTGAIILDL QASSLSAVAE KVVDELRTKG EIRAADRDGL LRALLQRRSQ 
181:	SEGAVAQPLG GDIEMQTFSV TKQRDTTDSV EASIVLSGVM DSLEKPAVAF VRLGDSVVIE 
241:	GALEAPVPVR FVFVLVGPSQ GGVDYHESGR AMAALMADWV FSLEAYLAPT NKELTNAIAD 
301:	FMDCGIVIPP TEIQDEGMLQ PIIDFQKKML KDRLRPSDTR IIFGGGAKAD EADEEPREDP 
361:	LARTGIPFGG MIKDMKRRYR HYISDFTDAL DPQVLAAVIF IYFAALSPAI TFGGLLADKT 
421:	EHMMGVSELM ISTCVQGIIF AFIAAQPTLV IGFSGPLLVF EEAFFAFCKS QEIEYIVGRI 
481:	WVGLWLVIIV VVIVAVEGSF LVKFISRFTQ EIFSILISLI FIYETFSKLG KIFKAHPLVL 
541:	NYEHLNDSLD NPFHPVVKEH IEYHEDGNKT VHEVIHERAY PNTALLSMCL MFGCFFIAYF 
601:	LRQFKNGHFL PGPIRRMIGD FGVPIAIFFM IAVDITIEDA YTQKLVVPKG LMVSNPNARG 
661:	WFINPLGEKK PFPAWMMGAC CVPALLVFIL IFLESQITTL IVSKPERKMV KGSGFHLDLL 
721:	ILVTMGGIAS LFGVPWLSAA TVRSVTHANA LTVMSKGPKP EIEKVLEQRI SGMLVAAMVG 
781:	VSILLEPILK MIPMTALFGI FLYMGITSLS GIQMWDRMLL LIVPRKYYPA DAYAQRVTTM 
841:	KMHLFTLIQM VCLGALWMVK MSAFSLALPF VLILTIPLRM AITGTLFTDK EMKCLDASDG 
901:	KVKFEEEPGE DMYESPLP