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2.A.31.2.1
Electroneutral Na+:HCO3- cotransporter (NBC)

Accession Number:Q9R1N3
Protein Name:NBCn1-D aka NBC2
Length:1218
Molecular Weight:135954.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Na+, bicarbonate

Cross database links:

RefSeq: NP_478118.1   
Entrez Gene ID: 117955   
Pfam: PF07565    PF00955   
KEGG: rno:117955   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016323 C:basolateral plasma membrane
GO:0031410 C:cytoplasmic vesicle
GO:0016021 C:integral to membrane
GO:0032420 C:stereocilium
GO:0005452 F:inorganic anion exchanger activity
GO:0015293 F:symporter activity
GO:0006820 P:anion transport
GO:0006814 P:sodium ion transport

References (10)

[1] “An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel.”  Choi I.et.al.   10850716
[2] “Immunoelectron microscopic localization of NBC3 sodium-bicarbonate cotransporter in rat kidney.”  Kwon T.-H.et.al.   10662737
[3] “Immunolocalization of electroneutral Na-HCO(3)(-) cotransporter in rat kidney.”  Vorum H.et.al.   11053051
[4] “Immunolocalization of NBC3 and NHE3 in the rat epididymis: colocalization of NBC3 and the vacuolar H+-ATPase.”  Pushkin A.et.al.   10975418
[5] “The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3-cotransport isoform 3.”  Park M.et.al.   12403779
[6] “NBCn1 is a basolateral Na+-HCO3- cotransporter in rat kidney inner medullary collecting ducts.”  Praetorius J.et.al.   15075186
[7] “Basolateral Na+-dependent HCO3- transporter NBCn1-mediated HCO3-influx in rat medullary thick ascending limb.”  Odgaard E.et.al.   14673192
[8] “Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.”  Reiners J.et.al.   16301216
[9] “Molecular and functional characterization of the electroneutral Na/HCO3 cotransporter NBCn1 in rat hippocampal neurons.”  Cooper D.S.et.al.   15718246
[10] “An anti-NH2-terminal antibody localizes NBCn1 to heart endothelia and skeletal and vascular smooth muscle cells.”  Damkier H.H.et.al.   16126812

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MEADGAGEQM RPLLTRGPDE EAVVDLGKTS STVNTKFEKE ELESHRAVYV GVHVPFSKES 
61:	RRRHRHRGHK HHHRRRKDKD SDKEDGRESP SYDTPSQRVQ FILGTEDDDE EHIPHDLFTE 
121:	MDELCYRDGE EYEWKETARW LKFEEDVEDG GDRWSKPYVA TLSLHSLFEL RSCILNGTVM 
181:	LDMRASTLDE IADMVLDNMI ASGQLDDSIR ENVREALLKR HHHQNEKRFT SRIPLVRSFA 
241:	DIGKKHSDPH LLERNGEGLS ASRHSLRTGL SASNLSLRGE SPLSLLLSHL LPSSRAGTPA 
301:	GSRCTTPVPT PQNSPPSSPS LSRLTSRSSQ QTQPQAPEVL VSPDRDDIPR VVIHPPEEDI 
361:	EALKGQEQKN EENTDFTPGI LASPQSAPGN LDSSKSGEVK GNGSGGSREN STVDFSKVDM 
421:	NFMRKIPTGA EASNVLVGEV DFLERPIIAF VRLAPAVLLS GLTEVPVPTR FLFLLLGPAG 
481:	KAPQYHEIGR SIATLMTDEI FHDVAYKAKD RNDLLSGIDE FLDQVTVLPP GEWDPSIRIE 
541:	PPKSVPSQEK RKIPAFPNGS APVSADPPKE ADHHAGPELQ RTGRLFGGLI LDIKRKAPFF 
601:	LSDFKDALSL QCLASILFLY CACMSPVITF GGLLGEATEG RISAIESLFG ASLTGIAYSL 
661:	FAGQPLTILG STGPVLVFEK ILFKFCRDYH LSYLSLRTSI GLWTSFLCIV LVATDASSLV 
721:	CYITRFTEEA FAALICIIFI YEALEKLFHL GEIYAFNMHN NLDALTSYTC VCAEPSNPSN 
781:	ETVELWERKN VTAASISWAN LTVSECKTFH GMFVGSACGP HGPYVPDVLF WCVVLFFTTF 
841:	FLSSFLKQFK TKRYFPTKVR STISDFAVFL TIVIMVAIDY LVGIPSPKLH VPEKFEPTDP 
901:	SRGWIISPLG DNPWWTLLIA AVPALLCTIL IFMDQQITAV IINRKEHKLK KGAGYHLDLL 
961:	MVAVMLGVCS IMGLPWFVAA TVLSISHVNS LKVESECSAP GEQPKFLGIR EQRVTGLMIF 
1021:	ILMGLSVFMT SVLKFIPMPV LYGVFLYMGV SSLKGIQFFD RIKLFGMPAK HQPDLIYLRY 
1081:	VPLWKVHVFT VVQLTCLVLL WVIKASAAAV VFPMMVLALV FVRKLMDLCF TKRELSWLDD 
1141:	LMPESKKKKE DDKKKKEKEE AERMLQGDGD TVHLPFERGS LLQIPVKTLK YSPEKPVSVT 
1201:	INFEDEPSKK YMDAETSL