2.A.31.2.16 Probable electroneutral Na+-driven bicarbonate transporter, NBC, of 1214 aas and 13 putative TMSs. It possibly functions by Cl- exchange as does the human ortholog (TC# 2.A.31.2.4). It is present in the flagellar plasma membrane (Gunaratne et al. 2006).
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Accession Number: | Q1A708 |
Protein Name: | Anion exchange protein |
Length: | 1214 |
Molecular Weight: | 135480.00 |
Species: | Strongylocentrotus purpuratus (Purple sea urchin) [7668] |
Number of TMSs: | 10 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
anion, sodium hydrogencarbonate |
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1: MDESDVVVDQ GNYHSLREAD ESETSGHHAI YVGVHVPHNE EQQQKNHHHH HHKHRHKGKS
61: KKNGSSHSSA NNSSSTADAF FPNNDPDARP DALLLDKNGD ASQRVKFILG DEADDGHESH
121: EIFTEMEELC YGSDGEELEW KEMARWIKYE EDVDVDADRW SKPHVATLPL HSLFELRTCL
181: INGTVCLDME ADNIVQIADL VLDKLIMSEQ LDESKREQVR EALLRKHHHQ SHKKHRDKRG
241: SSLLPMIRSL TDIGRSLSQG GAHNTSMEQQ AAAQSGIQTS HGSSPNIQNS QTSPSSLMVK
301: GNSGDLGKSE TSGSLPKVSS HHSLKKRLSE ARLSIPHNLA GHSLSARHSF MRKIPQGAEA
361: SNVLIGEVDF LSRPIIAFVR LQSAVSLGDP TEVPIPRRFL FILLGPQSGE TKRYHEIGRC
421: VATIMSDKVF HDVAYKAKST KDLLAGIDEF IDSVTVLPPG AWDPNIRIEP PKVVPDQAKR
481: LSHFQTPNGH AEGIDEEDGG GGGGHNGEHE GLERTGKIFG GLIQDCKRRF PFYLSDFKDA
541: FHLQCLASFI FMYFACITPV ITFGGLLGEA TENRMSALEG LLGASICGVA FHLFSGQPLT
601: ILGSTGPILV YEKILFGFCK TQELDYLSFR FWIGLWTMVF CVILVATDAS SFVKYFTRFI
661: EESFSSLISF IFIYESVHKL MKIYKEYPVA RYANDNTTYE CMCQTATGLF EYDEKDFYTE
721: SKIDCDSLNG TLVGNWCGKH VPQSDIFFMS LILMLGTFTI AYSLKEFKTT GYFPTIIRTT
781: VSDFAVLIAV VIMVGVDRLF GVDTPKLLVP SEFKPTSDLR KGWFIHPFNG NGWWTVLAAI
841: IPALLATILV FMDQQITAVI VNRKENKFKK GLGYHLDLLV VAVMLGICSI MGLPWFVAAT
901: VLSINHVNSL RVESECKAPG ERPKIVGCRE QRVTGVMVFV MIGLATLMTK ILSYVPMPVL
961: YGVFLFMGIA SLKGVQFVDR LSLFFMPLKY QPDYIYLRHV GIKKVYLFTF IQLMCLVVPM
1021: GIKSTDAAIV FPIMVLGMVV VRKLMDYVFT KQEVMMLDDV MPEMTKRAKH DRKKKQEEEV
1081: AACEQIKNIP GRVQVPLSDG NMLSIPVDKV EFHPEVACIN IPEDMAKTGV WKALAKNAEG
1141: GQVVHRKPHG KEKSSSGGRP NLDLPTIPGS PRESSYLETQ RGSIQEVRIE VPEQFRRTPS
1201: PPPTHIGTDN ETSV