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|---|---|
| Accession Number: | Q04121 |
| Protein Name: | Endosomal/prevacuolar sodium/hydrogen exchanger |
| Length: | 633 |
| Molecular Weight: | 70148.00 |
| Species: | Saccharomyces cerevisiae (Baker's yeast) [4932] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Endosome membrane1 / Multi-pass membrane protein2 |
| Substrate | sodium(1+), hydron |
Cross database links:
| DIP: | DIP-4145N DIP-4145N |
|---|---|
| Entrez Gene ID: | 852066 |
| Pfam: | PF00999 |
Gene Ontology
GO:0000329
C:fungal-type vacuole membrane
GO:0016021
C:integral to membrane
GO:0031902
C:late endosome membrane
GO:0015385
F:sodium:hydrogen antiporter activity
GO:0006813
P:potassium ion transport
GO:0007035
P:vacuolar acidification
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References (20)[1] “Identification of a mitochondrial Na+/H+ exchanger.” Numata M.et.al. 9507001 [2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.” Jacq C.et.al. 9169867 [3] “Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.” Raymond C.K.et.al. 1493335 [4] “Intracellular sequestration of sodium by a novel Na+/H+ exchanger in yeast is enhanced by mutations in the plasma membrane H+-ATPase. Insights into mechanisms of sodium tolerance.” Nass R.et.al. 9334180 [5] “Novel localization of a Na+/H+ exchanger in a late endosomal compartment of yeast. Implications for vacuole biogenesis.” Nass R.et.al. 9694857 [6] “The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock.” Nass R.et.al. 10589731 [7] “Arabidopsis thaliana and Saccharomyces cerevisiae NHX1 genes encode amiloride sensitive electroneutral Na(+)/H(+) exchangers.” Darley C.P.et.al. 10998367 [8] “The sodium/proton exchanger Nhx1p is required for endosomal protein trafficking in the yeast Saccharomyces cerevisiae.” Bowers K.et.al. 11102523 [9] “The yeast Na+/H+ exchanger Nhx1 is an N-linked glycoprotein. Topological implications.” Wells K.M.et.al. 11036065 [10] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106 [11] “Inhibition of sodium/proton exchange by a Rab-GTPase-activating protein regulates endosomal traffic in yeast.” Ali R.et.al. 14610088 [12] “The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking.” Brett C.L.et.al. 15635088 [13] “Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.” Gruhler A.et.al. 15665377 [14] “Physiological characterization of Saccharomyces cerevisiae kha1 deletion mutants.” Maresova L.et.al. 15659172 [15] “Mutational analysis of the intramembranous H10 loop of yeast Nhx1 reveals a critical role in ion homoeostasis and vesicle trafficking.” Mukherjee S.et.al. 16671892 [16] “Prevacuolar compartment morphology in vps mutants of Saccharomyces cerevisiae.” Hedman J.M.et.al. 17543551 [17] “Identification and characterization of Vnx1p, a novel type of vacuolar monovalent cation/H+ antiporter of Saccharomyces cerevisiae.” Cagnac O.et.al. 17588950 [18] “Chloride homeostasis in Saccharomyces cerevisiae: high affinity influx, V-ATPase-dependent sequestration, and identification of a candidate Cl-sensor.” Jennings M.L.et.al. 18378800 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MLSKVLLNIA FKVLLTTAKR AVDPDDDDEL LPSPDLPGSD DPIAGDPDVD LNPVTEEMFS 61: SWALFIMLLL LISALWSSYY LTQKRIRAVH ETVLSIFYGM VIGLIIRMSP GHYIQDTVTF 121: NSSYFFNVLL PPIILNSGYE LNQVNFFNNM LSILIFAIPG TFISAVVIGI ILYIWTFLGL 181: ESIDISFADA MSVGATLSAT DPVTILSIFN AYKVDPKLYT IIFGESLLND AISIVMFETC 241: QKFHGQPATF SSVFEGAGLF LMTFSVSLLI GVLIGILVAL LLKHTHIRRY PQIESCLILL 301: IAYESYFFSN GCHMSGIVSL LFCGITLKHY AYYNMSRRSQ ITIKYIFQLL ARLSENFIFI 361: YLGLELFTEV ELVYKPLLII VAAISICVAR WCAVFPLSQF VNWIYRVKTI RSMSGITGEN 421: ISVPDEIPYN YQMMTFWAGL RGAVGVALAL GIQGEYKFTL LATVLVVVVL TVIIFGGTTA 481: GMLEVLNIKT GCISEEDTSD DEFDIEAPRA INLLNGSSIQ TDLGPYSDNN SPDISIDQFA 541: VSSNKNLPNN ISTTGGNTFG GLNETENTSP NPARSSMDKR NLRDKLGTIF NSDSQWFQNF 601: DEQVLKPVFL DNVSPSLQDS ATQSPADFSS QNH