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2.A.36.1.15 Sodium/hydrogen exchanger 3 (Na⁺/H⁺ exchanger 3) (NHE-3) of 834 aas and 12 TMSs (Solute carrier family 9 member 3) (Dominguez Rieg et al. 2016). SLC9A3 deficiency-mediated micturition dysfunction is caused by electrolyte imbalance (Chen et al. 2023).
Accession Number:	P48764
Protein Name:	Sodium/hydrogen exchanger 3
Length:	834
Molecular Weight:	92855.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	sodium(1+), hydron

Entrez Gene ID:	6550
Pfam:	PF00999
KEGG:	hsa:6550
Gene Ontology GO:0016324 C:apical plasma membrane GO:0005903 C:brush border GO:0031526 C:brush border membrane GO:0009986 C:cell surface GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015385 F:sodium:hydrogen antiporter activity GO:0007623 P:circadian rhythm GO:0006898 P:receptor-mediated endocytosis GO:0006885 P:regulation of pH GO:0002028 P:regulation of sodium ion transport GO:0051384 P:response to glucocorticoid stimulus
References (4) [1] “Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3.” Brant S.R.et.al. 7631746 [2] “The DNA sequence and comparative analysis of human chromosome 5.” Schmutz J.et.al. 15372022 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.” Zachos N.C.et.al. 19088451

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MWGLGARGPD RGLLLALALG GLARAGGVEV EPGGAHGESG GFQVVTFEWA HVQDPYVIAL 
61:	WILVASLAKI GFHLSHKVTS VVPESALLIV LGLVLGGIVW AADHIASFTL TPTVFFFYLL 
121:	PPIVLDAGYF MPNRLFFGNL GTILLYAVVG TVWNAATTGL SLYGVFLSGL MGDLQIGLLD 
181:	FLLFGSLMAA VDPVAVLAVF EEVHVNEVLF IIVFGESLLN DAVTVVLYNV FESFVALGGD 
241:	NVTGVDCVKG IVSFFVVSLG GTLVGVVFAF LLSLVTRFTK HVRIIEPGFV FIISYLSYLT 
301:	SEMLSLSAIL AITFCGICCQ KYVKANISEQ SATTVRYTMK MLASSAETII FMFLGISAVN 
361:	PFIWTWNTAF VLLTLVFISV YRAIGVVLQT WLLNRYRMVQ LEPIDQVVLS YGGLRGAVAF 
421:	ALVVLLDGDK VKEKNLFVST TIIVVFFTVI FQGLTIKPLV QWLKVKRSEH REPRLNEKLH 
481:	GRAFDHILSA IEDISGQIGH NYLRDKWSHF DRKFLSRVLM RRSAQKSRDR ILNVFHELNL 
541:	KDAISYVAEG ERRGSLAFIR SPSTDNVVNV DFTPRSSTVE ASVSYLLREN VSAVCLDMQS 
601:	LEQRRRSIRD AEDMVTHHTL QQYLYKPRQE YKHLYSRHEL TPTEDEKQDR EIFHRTMRKR 
661:	LESFKSTKLG LNQNKKAAKL YKRERAQKRR NSSIPNGKLP MESPAQNFTI KEKDLELSDT 
721:	EEPPNYDEEM SGGIEFLASV TKDTASDSPA GIDNPVFSPD EALDRSLLAR LPPWLSPGET 
781:	VVPSQRARTQ IPYSPGTFCR LMPFRLSSKS VDSFLQADGP EERPPAALPE STHM

2.A.36.1.15
Sodium/hydrogen exchanger 3 (Na⁺/H⁺ exchanger 3) (NHE-3) of 834 aas and 12 TMSs (Solute carrier family 9 member 3) (Dominguez Rieg et al. 2016). SLC9A3 deficiency-mediated micturition dysfunction is caused by electrolyte imbalance (Chen et al. 2023).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

2.A.36.1.15Sodium/hydrogen exchanger 3 (Na+/H+ exchanger 3) (NHE-3) of 834 aas and 12 TMSs (Solute carrier family 9 member 3) (Dominguez Rieg et al. 2016). SLC9A3 deficiency-mediated micturition dysfunction is caused by electrolyte imbalance (Chen et al. 2023).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

2.A.36.1.15
Sodium/hydrogen exchanger 3 (Na⁺/H⁺ exchanger 3) (NHE-3) of 834 aas and 12 TMSs (Solute carrier family 9 member 3) (Dominguez Rieg et al. 2016). SLC9A3 deficiency-mediated micturition dysfunction is caused by electrolyte imbalance (Chen et al. 2023).