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2.A.36.1.18
Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4).  NHE4 had previously been suggested to play a critical role in renal ammonia metabolism through its role in thick ascending limb (TAL) ammonia transport. Lee et al. 2025 showed that its deletion does not alter renal ammonia handling and that neither the mouse nor human kidney expresses NHE4 in the TAL.

Accession Number:Q6AI14
Protein Name:Sodium/hydrogen exchanger 4
Length:798
Molecular Weight:89814.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), hydron

Cross database links:

Entrez Gene ID: 389015   
Pfam: PF00999   
KEGG: hsa:389015   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006811 P:ion transport
GO:0006885 P:regulation of pH
GO:0055085 P:transmembrane transport

References (3)

[1] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[2] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[3] “Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.”  Denis N.J.et.al.   17370265

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MALQMFVTYS PWNCLLLLVA LECSEASSDL NESANSTAQY ASNAWFAAAS SEPEEGISVF 
61:	ELDYDYVQIP YEVTLWILLA SLAKIGFHLY HRLPGLMPES CLLILVGALV GGIIFGTDHK 
121:	SPPVMDSSIY FLYLLPPIVL EGGYFMPTRP FFENIGSILW WAVLGALINA LGIGLSLYLI 
181:	CQVKAFGLGD VNLLQNLLFG SLISAVDPVA VLAVFEEARV NEQLYMMIFG EALLNDGITV 
241:	VLYNMLIAFT KMHKFEDIET VDILAGCARF IVVGLGGVLF GIVFGFISAF ITRFTQNISA 
301:	IEPLIVFMFS YLSYLAAETL YLSGILAITA CAVTMKKYVE ENVSQTSYTT IKYFMKMLSS 
361:	VSETLIFIFM GVSTVGKNHE WNWAFICFTL AFCQIWRAIS VFALFYISNQ FRTFPFSIKD 
421:	QCIIFYSGVR GAGSFSLAFL LPLSLFPRKK MFVTATLVVI YFTVFIQGIT VGPLVRYLDV 
481:	KKTNKKESIN EELHIRLMDH LKAGIEDVCG HWSHYQVRDK FKKFDHRYLR KILIRKNLPK 
541:	SSIVSLYKKL EMKQAIEMVE TGILSSTAFS IPHQAQRIQG IKRLSPEDVE SIRDILTSNM 
601:	YQVRQRTLSY NKYNLKPQTS EKQAKEILIR RQNTLRESMR KGHSLPWGKP AGTKNIRYLS 
661:	YPYGNPQSAG RDTRAAGFSD DDSSDPGSPS ITFSACSRIG SLQKQEAQEI IPMKSLHRGR 
721:	KAFSFGYQRN TSQEEYLGGV RRVALRPKPL FHAVDEEGES GGESEGKASL VEVRSRWTAD 
781:	HGHGRDHHRS HSPLLQKK