| |
|---|---|
| Accession Number: | Q9Y2E8 |
| Protein Name: | Sodium/hydrogen exchanger 8 |
| Length: | 581 |
| Molecular Weight: | 65422.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Golgi apparatus membrane1 / Multi-pass membrane protein2 |
| Substrate | sodium(1+) |
Cross database links:
| RefSeq: | NP_056081.1 |
|---|---|
| Entrez Gene ID: | 23315 |
| Pfam: | PF00999 |
| KEGG: | hsa:23315 hsa:23315 |
Gene Ontology
GO:0000139
C:Golgi membrane
GO:0016021
C:integral to membrane
GO:0015385
F:sodium:hydrogen antiporter activity
GO:0006885
P:regulation of pH
GO:0006814
P:sodium ion transport
GO:0055085
P:transmembrane transport
GO:0015386
F:potassium:hydrogen antiporter activity
GO:0006811
P:ion transport
GO:0051453
P:regulation of intracellular pH
| |
References (16)[1] “Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.” Nagase T.et.al. 10231032 [2] “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.” Nakajima D.et.al. 12168954 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [5] “The DNA sequence and comparative analysis of human chromosome 20.” Deloukas P.et.al. 11780052 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi Compartments and are involved in organelle pH regulation.” Nakamura N.et.al. 15522866 [8] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [9] “Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.” Nagase T.et.al. 10231032 [10] “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.” Nakajima D.et.al. 12168954 [11] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [12] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 | |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MGEKMAEEER FPNTTHEGFN VTLHTTLVVT TKLVLPTPGK PILPVQTGEQ AQQEEQSSGM 61: TIFFSLLVLA ICIILVHLLI RYRLHFLPES VAVVSLGILM GAVIKIIEFK KLANWKEEEM 121: FRPNMFFLLL LPPIIFESGY SLHKGNFFQN IGSITLFAVF GTAISAFVVG GGIYFLGQAD 181: VISKLNMTDS FAFGSLISAV DPVATIAIFN ALHVDPVLNM LVFGESILND AVSIVLTNTA 241: EGLTRKNMSD VSGWQTFLQA LDYFLKMFFG SAALGTLTGL ISALVLKHID LRKTPSLEFG 301: MMIIFAYLPY GLAEGISLSG IMAILFSGIV MSHYTHHNLS PVTQILMQQT LRTVAFLCET 361: CVFAFLGLSI FSFPHKFEIS FVIWCIVLVL FGRAVNIFPL SYLLNFFRDH KITPKMMFIM 421: WFSGLRGAIP YALSLHLDLE PMEKRQLIGT TTIVIVLFTI LLLGGSTMPL IRLMDIEDAK 481: AHRRNKKDVN LSKTEKMGNT VESEHLSELT EEEYEAHYIR RQDLKGFVWL DAKYLNPFFT 541: RRLTQEDLHH GRIQMKTLTN KWYEEVRQGP SGSEDDEQEL L