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2.A.36.4.3
Na+:H+ antiporter, Nha1 or Sod2 of 468 aas and 12 or 13 TMSs.  It provides salt tolerance by removing sodium and lithium ions in exchange for protons, and TMS 4 plays an important role (Ullah et al. 2013). The Asp266/Asp267 pair are critical for Sod2 function (Fliegel 2005). Residues within TMS 11 also play important roles in transport, suggesting that this TMS forms part of the ion translocation core (Dutta et al. 2017). Conserved transmembrane charged residues and a yeast-specific extracellular loop are also important for function (Dutta et al. 2019).

Accession Number:P36606
Protein Name:NAH aka Nha1 aka SOD2 aka SPAC977.10
Length:468
Molecular Weight:52177.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate lithium(1+), sodium(1+), hydron

Cross database links:

RefSeq: NP_592782.1   
Entrez Gene ID: 2543239   
Pfam: PF00999   
KEGG: spo:SPAC977.10   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0042175 C:nuclear membrane-endoplasmic reticulum network
GO:0005886 C:plasma membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006883 P:cellular sodium ion homeostasis
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.”  Jia Z.-P.et.al.   1314171
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[3] “Identification and localization of the sod2 gene product in fission yeast.”  Dibrov P.et.al.   9094438
[4] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517
Structure:
2M7X     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGWRQLDIDK VHLALIVAGG FITFFCYFSE VFRKKLLVGE AVLGSITGLI FGPHAAKLVD 
61:	PFSWGDHGDY LTVEICRIVL DVRVFASAIE LPGAYFQHNF RSIIVMLLPV MAYGWLVTAG 
121:	FAYALFPQIN FLGSLLIAGC ITSTDPVLSA LIVGEGPLAK KTPERIRSLL IAESGCNDGM 
181:	AVPFFYFAIK LLTVKPSRNA GRDWVLLVVL YECAFGIFFG CVIGYLLSFI LKHAQKYRLI 
241:	DAISYYSLPL AIPLLCSGIG TIIGVDDLLM SFFAGILFNW NDLFSKNISA CSVPAFIDQT 
301:	FSLLFFTYYG TIIPWNNFNW SVEGLPVWRL IVFSILTLVC RRLPVVFSVK PLVPDIKTWK 
361:	EALFVGHFGP IGVCAVYMAF LAKLLLSPDE IEKSIYESTT VFSTLNEIIW PIISFVILSS 
421:	IIVHGFSIHV LVIWGKLKSL YLNRKVTKSD SDLELQVIGV DKSQEDYV